Application and biomechanical study of porous titanium alloy support rod in ankle joint injuries

doi:10.3969/j.issn.2095-4344.2017.34.001

Abstract

Abstract:

BACKGROUND: Studies have shown that titanium alloy with good biocompatibility can be easily processed and synthesized to produce a porous structure with suitable pore diameter, which shows desired outcomes in the treatment of ankle injury. Its mechanical performance, however, is yet unclear.

OBJECTIVE: To investigate the effect and biomechanical properties of porous titanium alloy support rod in ankle joint injuries.

METHODS: The lateral ligaments of the ankle were lifted and ripped violently using a hemostatic forceps to make ankle injury models in 30 healthy Beagle dogs. Animal models were randomized into two groups: control and experimental groups (n=15 per group). A three-dimensional model of porous titanium alloy rod was established by using CAD software, and it was input into the EBM S12 system. Ti6A14V powder was added into the machine and melted layer by layer, and then made into porous cylinder rods of 4 mm in diameter and 12 mm in length. The control group used conventional repair, and the experimental group underwent repair with porous titanium alloy support rod implantation. Degree of ankle swelling, excellent/good repair rate, and electrophysiological and biomechanical properties were compared between two groups.

RESULTS AND CONCLUSION: Ipsilateral ankle circumference showed no difference between the two groups before treatment (P > 0.05), but after repair with porous titanium alloy support rod implantation, the experimental groups had significantly lower ipsilateral ankle circumference than the control group (P < 0.05). The excellent/good rate was also significantly higher in the experimental group than the control group at 3 months after repair (P < 0.05). For the somatosensory evoked potential and electromyogram of the affected lateral ligament of the ankle, significantly lower latency and significantly higher amplitude was found in the experimental group than the control group at 3 months after repair, though there was no significant difference between the two groups before repair (P > 0.05). Maximum perturbation, elastic disturbance and damage immunity had no significant difference between the two group (P > 0.05), while the experimental group had significantly increased maximum load, elastic load, failure load and stiffness coefficient compared with the control group (P < 0.05). Overall, the porous titanium alloy support rod can achieve good outcomes in the repair of ankle injury, and help to improve the biomechanical properties of the ankle.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Lateral Ligament, Ankle, Titanium, Biomechanics, Tissue Engineering

CLC Number:

R318

Li Da-cheng, Fu Ying, Chen Wang-jun, Feng Kua.

Application and biomechanical study of porous titanium alloy support rod in ankle joint injuries

[J]. Chinese Journal of Tissue Engineering Research, 2017, 21(34): 5413-5417.

Figures/Tables 4

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