Chinese Journal of Tissue Engineering Research ›› 2017, Vol. 21 ›› Issue (4): 559-563.doi: 10.3969/j.issn.2095-4344.2017.04.011

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Expression of heat shock protein 70 in periodontium during orthodontic tooth movement

Nie Jing1, Jiang Han2, Li Ze-hui2, Pan Xu1, Li Chun-xia1   

  1. 1Department of Orthodontics; 2Department of Periodontics, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China
  • Received:2017-01-06 Online:2017-02-08 Published:2017-03-13
  • Contact: Corresponding author: Nie Jing, the First Teaching Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China
  • About author:Nie Jing, Master, Department of Orthodontics, the First Teaching Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China
  • Supported by:

    the Youth Project of the Natural Science Foundation of Xinjiang Uygur Autonomous Region, No. 2014211C080

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Abstract:

Abstract
BACKGROUND: Extensive research has been concentrated on the reconstruction of periodontium under orthodontic force. However, there are no reports regarding the expression of heat shock protein 70 (HSP70) in rat periodontium during orthodontic tooth movement.
OBJECTIVE: To investigate the expression of HSP70 in rat periodontium during orthodontic tooth movement.
METHODS: Rat orthodontic tooth movement models were established using NiTi extension spring with the force of 50 g. The orthodontic periodontium was collected at 1, 3, 5, 7, 10 and 14 days after exerting force to detect the expression of HSP70. 
RESULTS AND CONCLUSION: According to immunofluorescence staining, the expression of HSP70 in the periodontal tissues was increased on day 1 after exerting force, and reached the highest level on day 5, then decreased to the initial level on day 14. These results suggest that the expression of HSP70 is evoked by orthodontic force, and it may play a role in periodontal remodeling.

Key words: Tissue Engineering, Heat-Shock Proteins, Osteoblasts

CLC Number: