Pathogenesis of synovitis in knee osteoarthritis patients

doi:10.3969/j.issn.2095-4344.2015.51.023

Abstract

Abstract:

BACKGROUND: We gradually realize that inflammatory changes in the knee synovial membrane play an important role in the pathogenesis of knee osteoarthritis.
OBJECTIVE: To summarize the studies on the pathogenesis of synovitis in knee osteoarthritis patients in recent 15 years and to conclude the experimental achievements in the molecular biology.
METHODS: Wanfang database, VIP information resource system, CNKI database and PubMed database were retrieved using the keywords of "osteoarthritis, synovitis, pathogenesis” for articles addressing the pathogenesis of synovitis in knee osteoarthritis, which were published from 2000 to 2015. Totally 3 446 articles were retrieved, and finally 36 articles were included in result analysis.
RESULTS AND CONCLUSION: Synovitis of the knee may be a super-early manifestation of knee osteoarthritis, which can influence osteoarthritis progression. In the formation of osteoarthritis, the autoinflammatory reaction of the synovium, released inflammatory mediators, cytokines and proteins exert important role in the occurrence of diseases. Until today, however, we cannot elaborate the accepted pathogenesis of synovitis at the molecular level.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

CLC Number:

R318

Ding Cheng-biao, Zhou Yun. Pathogenesis of synovitis in knee osteoarthritis patients[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(51): 8327-8332.

Figures/Tables 1

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