Autologous chondrocyte transplantation for knee joint cartilage repair: MRI assessment of biomechanical changes

doi:10.3969/j.issn.2095-4344.2015.51.009

Abstract

Abstract:

BACKGROUND: MRI examination is considered as the best noninvasive method to detect the articular cartilage. Cartilage and subchondral bone defects can be detected through MRI examination.
OBJECTIVE: To explore the biomechanical changes of the cartilage in articular cartilage defects of the knee after autologous chondrocyte transplantation through MRI examination.
METHODS: The clinical data of 10 patients with articular cartilage defects who underwent autologous chondrocyte transplantation were analyzed retrospectively. All patients were followed up for 12 months, and the Knee Injury and Osteoarthritis Outcome Score (KOOS) and MRI examination were performed at 3, 6, 12 months after transplantation.

RESULTS AND CONCLUSION: All the patients exhibited a great improvement in the KOOS scores in terms of pain, symptoms, daily activities, sports and entertainment, various indicators of quality of life at 3, 6 and 12 months after transplantation (P < 0.05). MRI findings showed that the injured cartilage was mostly filled well at 3 months; the transplanted chondrocytes were basically integrated with the surrounding cartilage tissues at 6 months; the signal intensity of the repaired tissues was consistent with that of the surrounding tissues. As time went on, the T2 value of the transplanted area showed a continuous decline. Moreover, the T2 values at 3, 6 and 12 months after transplantation were significantly lower than that before transplantation (P < 0.05); the T2 values at 6 and 12 months after transplantation were significantly less than that at 3 months after transplantation (P < 0.05); the T2 values in the transplanted area before and 3 months after transplantation were significantly greater than those in the normal region (P < 0.05). These findings indicate that MRI examination is a safe and noninvasive follow-up method to understand the biomechanical changes of the cartilage in articular cartilage defects of the knee after autologous chondrocyte transplantation and monitor the therapeutic efficacy.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

CLC Number:

R318

Guo Hong-bin, Guo Ying-xin, Yu Wei, Ding Chun-ping, Cai Li-zhong, Li Min-yang. Autologous chondrocyte transplantation for knee joint cartilage repair: MRI assessment of biomechanical changes[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(51): 8247-8252.

Figures/Tables 4

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