Pericyte-related signaling pathways in angiogenesis

doi:10.3969/j.issn.2095-4344.2015.46.023

Abstract

Abstract:

BACKGROUND: Pericytes, which are widely distributed in the microvasculature except lymphatic vessels, are not only a constituent of microvessels, but also play an important role in microvascular occurrence, development, stability, maturity and remodeling. Its signal transduction is currently a hot spot.

OBJECTIVE: To review recent advances in the signal pathways related to pericytes and angiogenesis.

METHODS: We retrieved PubMed database, Wanfang database, CNKI database and China Biology Medicine disc for articles addressing pericytes and angiogenesis published from 1994 to 2014. The keywords were “pricytes; endothelial cells; microvessels; signal transduction” in English and Chinese, respectively.

RESULTS AND CONCLUSION: In the early stage of capillary formation, recruitment of pericytes contributes to the occurrence and development of new blood capillaries. However, in the late stage of angiogenesis, pericytes inhibit endothelial cell proliferation and promote endothelial cell differentiation, thereby promoting vascular maturation, maintaining normal structure and regulating their permeability. In this process, signaling pathways of platelet-derived growth factor B/platelet-derived growth factor receptor β, transforming growth factor β, angiopoietin-1/Tie-2, human heparin binding epidermal growth factor/ErbBs, and stromal cell derived factor 1α/CXCR4 play an important regulatory role in pericytes and angiogenesis.
中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Platelet-Derived Growth Factors, Receptors, Platelet-Derived Growth Factor, Endothelial Cells, Capillaries

Jiang Fu-lin, Ai Dong-qing, Guan Qiu-yue. Pericyte-related signaling pathways in angiogenesis[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(46): 7504-7508.

Figures/Tables 1

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