Chinese Journal of Tissue Engineering Research ›› 2015, Vol. 19 ›› Issue (41): 6718-6724.doi: 10.3969/j.issn.2095-4344.2015.41.028

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Theory and efficacy of stem cells from different sources in the treatment of diabetic foot

Chen Gao-yang, Chang Fei, Li Rui, Zhang Han-yang, Dong Quan-yu, Jiang Zhen-de, Liu Mao-sheng   

  1. Second Hospital of Jilin University, Changchun 130000, Jilin Province, China
  • Online:2015-10-01 Published:2015-10-01
  • Contact: Chang Fei, M.D., Associate chief physician, Second Hospital of Jilin University, Changchun 130000, Jilin Province, China
  • About author:Chen Gao-yang, Studying for master’s degree, Second Hospital of Jilin University, Changchun 130000, Jilin Province, China

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Abstract:

BACKGROUND: Stem cell is a kind of pluripotent cells with self-replication ability, which can differentiate into various cells under certain conditions. Furthermore, stem cells are rich in a variety of growth factors, which can induce the generation of vessels and nerves, and improve the blood supply of lower limbs, thereby achieving the treatment and preventions of lower limb ischemia

OBJECTIVE: To summarize and compare the recent achievements in the theory and therapeutic efficacy of stem cells from different sources in the treatment of diabetic foot.
METHODS: The first and second authors retrieved PubMed, Sciencedirect and Medline databases for relevant articles published from January 2000 to January 2015. The key words were “diabetic foot, pathogenesis, stem cell therapy” in English. Initially, 186 articles were retrieved, and finally 44 articles were included in result analysis.
RESULTS AND CONCLUSION: Stem cells can be a new choice for the treatment of diabetic foot. After stem cell therapy, corresponding symptoms have been alleviated, including the generation of new blood vessels and the reshaping of the collateral vessels, the improvement of motor nerve conduction velocity and nerve reflex, the improvement of the sense of skin pain and temperature, and pain relief. It is still unclear whether allogeneic stem cells are safe or not, but autologous stem cells, especially bone marrow mesenchymal stem cells, can be better able to repair damaged vessels and nerves and restore the microcirculation of blood supply. Currently, we need to do more basic and clinical researches to solve the following problems: to confirm the effectiveness and safety of stem cell therapy for diabetic foot; to identify whether there is a difference in the differentiation and secretory activity between stem cells in diabetic patients and ordinary people; to give full play to the treatment of diabetic foot.

Key words: Diabetic Foot, Cytokines, Mesenchymal Stem Cells, Monocytes, Tissue Engineering