Articular cartilage repair using mesenchymal stem cells-derived microvesicles and induced pluripotent stem cells

doi:10.3969/j.issn.2095-4344.2015.41.026

Abstract

Abstract:

BACKGROUND: Induced pluripotent stem cells and mesenchymal stem cells-derived microvesicles have been confirmed in various tissue repairs, which are expected to become more effective and safe therapy for articular cartilage repair.
OBJECTIVE: To overall understand the research progress in the use of induced pluripotent stem cells and mesenchymal stem cells-derived microvesicles in articular cartilage repair.
METHODS: A computer-based search of PubMed and CNKI was performed by the first author for articles related to stem cell treatment of osteoarthritis published from 2003 to 2015. The keywords were “articular cartilage injury, bone marrow mesenchymal stem cells” in English and Chinese, respectively. In the same field, articles published recently or in authorized journals were preferred.
RESULTS AND CONCLUSION: Articular cartilage injury is still a difficulty in the orthopedics. Many repair methods have been reported, but they all have limitations. Induced pluripotent stem cells and mesenchymal stem cells-derived microvesicles bring a new hope for patients with articular cartilage injury. However, there are still many problems to be solved, such as extracting and purifying a large amount of cells, proliferation and differentiation potentials, and mechanism underlying cartilage repair.
中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

Key words: Cartilage Diseases, Cartilage, Articular, Induced Pluripotent Stem Cells, Mesenchymal Stem Cells, Tissue Engineering

Hou Wei-yu, Cheng Yan-wei, Xiang Chuan . Articular cartilage repair using mesenchymal stem cells-derived microvesicles and induced pluripotent stem cells[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(41): 6706-6710.

Figures/Tables 1

References

[1] Piasecki DP, Spindler KP, Warren TA, et al. Intraarticular injuries associated with anterior cruciate ligament tear: findings at ligament reconstruction in high school and recreational athletes. An analysis of sex-based differences. Am J Sports Med. 2003;31(4):601-605.

[2] 邱贵兴. 骨关节炎流行病学和病因学新进展[J].继续医学教育, 2006,19(7): 68-69.

[3] 郭世绂.关节软骨的形态、生理、生化特征及损伤修复[J].骨与关节损伤杂志,1995,10(1):61-64.

[4] 李世和. 损伤控制理论在创伤骨科中的指导作用[J].中华创伤骨科杂志,2008,10(3):285-288.

[5] 兰纯娜,张长杰.关节软骨的损伤与康复[J].中华物理医学与康复杂志,2004,26(11):698-700.

[6] Beris AE, Lykissas MG, Papageorgiou CD, et al. Advances in articular cartilage repair. Injury. 2005;36 Suppl 4:S14-23.

[7] Bonnet CS, Walsh DA. Osteoarthritis, angiogenesis and inflammation. Rheumatology (Oxford). 2005;44(1):7-16.

[8] Magnussen RA, Dunn WR, Carey JL, et al. Treatment of focal articular cartilage defects in the knee: a systematic review. Clin Orthop Relat Res. 2008;466(4):952-962.

[9] Kinner B, Capito RM, Spector M. Regeneration of articular cartilage. Adv Biochem Eng Biotechnol. 2005;94:91-123.

[10] Noble BS, Dean V, Loveridge N, et al. Dextran sulfate promotes the rapid aggregation of porcine bone-marrow stromal cells. Bone. 1995;17(4):375-382.

[11] Wakitani S, Nawata M, Tensho K, et al. Repair of articular cartilage defects in the patello-femoral joint with autologous bone marrow mesenchymal cell transplantation: three case reports involving nine defects in five knees. J Tissue Eng Regen Med. 2007;1(1):74-79.

[12] Davatchi F, Abdollahi BS, Mohyeddin M, et al. Mesenchymal stem cell therapy for knee osteoarthritis. Preliminary report of four patients. Int J Rheum Dis. 2011;14(2):211-215.

[13] Bigdeli N, Karlsson C, Strehl R, et al. Coculture of human embryonic stem cells and human articular chondrocytes results in significantly altered phenotype and improved chondrogenic differentiation. Stem Cells. 2009;27(8): 1812-1821.

[14] Jarvinen L, Badri L, Wettlaufer S, et al. Lung resident mesenchymal stem cells isolated from human lung allografts inhibit T cell proliferation via a soluble mediator. J Immunol. 2008;181(6):4389-4396.

[15] Stagg J, Pommey S, Eliopoulos N, et al. Interferon-gamma- stimulated marrow stromal cells: a new type of nonhematopoietic antigen-presenting cell. Blood. 2006; 107(6):2570-2577.

[16] Brune JC, Tormin A, Johansson MC, et al. Mesenchymal stromal cells from primary osteosarcoma are non-malignant and strikingly similar to their bone marrow counterparts. Int J Cancer. 2011;129(2):319-330.

[17] Kidd S, Spaeth E, Watson K, et al. Origins of the tumor microenvironment: quantitative assessment of adipose- derived and bone marrow-derived stroma. PLoS One. 2012; 7(2):e30563.

[18] Simpson RJ, Jensen SS, Lim JW. Proteomic profiling of exosomes: current perspectives. Proteomics. 2008;8(19): 4083-4099.

[19] Cocucci E, Racchetti G, Meldolesi J. Shedding microvesicles: artefacts no more. Trends Cell Biol. 2009;19(2):43-51.

[20] Pap E, Pállinger E, Pásztói M, et al. Highlights of a new type of intercellular communication: microvesicle-based information transfer. Inflamm Res. 2009;58(1):1-8.

[21] 姚嘉,张英才,唐晖,等.间充质干细胞来源的微囊泡对大鼠肝脏缺血再灌注损伤的保护作用研究[C]. 2013中国器官移植大会论文汇编,2013.

[22] Bruno S, Grange C, Deregibus MC, et al. Mesenchymal stem cell-derived microvesicles protect against acute tubular injury. J Am Soc Nephrol. 2009;20(5):1053-1067.

[23] Bruno S, Grange C, Collino F, et al. Microvesicles derived from mesenchymal stem cells enhance survival in a lethal model of acute kidney injury. PLoS One. 2012;7(3):e33115.

[24] 王喜梅,杨跃进,吴永健.微囊泡在组织再生中的研究进展[J].医学综述,2012,18(13):1993-1995.

[25] Zhang HC, Liu XB, Huang S, et al. Microvesicles derived from human umbilical cord mesenchymal stem cells stimulated by hypoxia promote angiogenesis both in vitro and in vivo. Stem Cells Dev. 2012;21(18):3289-3297.

[26] Zhu YG, Feng XM, Abbott J, et al. Human mesenchymal stem cell microvesicles for treatment of Escherichia coli endotoxin- induced acute lung injury in mice. Stem Cells. 2014; 32(1): 116-125.

[27] Mokarizadeh A, Rezvanfar MA, Dorostkar K, et al. Mesenchymal stem cell derived microvesicles: trophic shuttles for enhancement of sperm quality parameters. Reprod Toxicol. 2013;42:78-84.

[28] Strassburg S, Hodson NW, Hill PI, et al. Bi-directional exchange of membrane components occurs during co-culture of mesenchymal stem cells and nucleus pulposus cells. PLoS One. 2012;7(3):e33739.

[29] Diao HJ, Yeung CW, Yan CH, et al. Bidirectional and mutually beneficial interactions between human mesenchymal stem cells and osteoarthritic chondrocytes in micromass co-cultures. Regen Med. 2013;8(3):257-269.

[30] Mokarizadeh A, Delirezh N, Morshedi A, et al. Microvesicles derived from mesenchymal stem cells: potent organelles for induction of tolerogenic signaling. Immunol Lett. 2012;147 (1-2): 47-54.

[31] Lai RC, Arslan F, Lee MM, et al. Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury. Stem Cell Res. 2010;4(3):214-222.

[32] Farsad K. Exosomes: novel organelles implicated in immunomodulation and apoptosis. Yale J Biol Med. 2002; 75(2):95-101.

[33] Uccelli A, Moretta L, Pistoia V. Mesenchymal stem cells in health and disease. Nat Rev Immunol. 2008;8(9):726-736.

[34] Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006;126(4):663-676.

[35] Boland MJ, Hazen JL, Nazor KL, et al. Adult mice generated from induced pluripotent stem cells. Nature. 2009;461(7260): 91-94.

[36] Hou P, Li Y, Zhang X, et al. Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. Science. 2013;341(6146):651-654.

[37] Zou XH, Zhi YL, Chen X, et al. Mesenchymal stem cell seeded knitted silk sling for the treatment of stress urinary incontinence. Biomaterials. 2010;31(18):4872-4879.

[38] Diekman BO, Guilak F. Stem cell-based therapies for osteoarthritis: challenges and opportunities. Curr Opin Rheumatol. 2013;25(1):119-126.

[39] Kim MJ, Son MJ, Son MY, et al. Generation of human induced pluripotent stem cells from osteoarthritis patient-derived synovial cells. Arthritis Rheum. 2011;63(10):3010-3021.

[40] Lee J, Kim Y, Yi H, et al. Generation of disease-specific induced pluripotent stem cells from patients with rheumatoid arthritis and osteoarthritis. Arthritis Res Ther. 2014;16(1):R41.

[41] Reardon S, Cyranoski D. Japan stem-cell trial stirs envy. Nature. 2014;513(7518):287-288.

Yamashita A, Morioka M, Kishi H, et al. Statin treatment rescues FGFR3 skeletal dysplasia phenotypes. Nature. 2014; 513(7519):507-511.