NovaBone for repair of limb fractures: its effect on bone graft fusion

doi:10.3969/j.issn.2095-4344.2015.38.010

Abstract

Abstract:

BACKGROUND: As a new kind of bone repair material, NovaBone has a unique biological activity and good biocompatibility. It has a good binding role in the clinical repair of bone defects, so as to effectively promote the bonding of soft tissue and bone tissue.
OBJECTIVE: To explore the clinical effect of NovaBone in the repair of bone defects due to limb fractures.
METHODS: Sixty-seven patients with bone defects due to limb fractures were enrolled, 37 males and 30 females, aged 17-81 years. All the patients underwent NovaBone repair. Three days after repair, routine blood test, heart and kidney function, serum complement C3, complement C4, immunoglobulin G, immunoglobulin A, immunoglobulin M were detected; 12 months after repair, X-ray observation was performed for bone graft fusion effect.
RESULTS AND CONCLUSION: All patients presented with stage I healing, and there was no incision infection, rejection or non-specific inflammation. Patients felt no discomfort or developed symptoms in the bone graft region. Laboratory indexes showed no abnormity. At 12 months after treatment, bony union was seen in all patients, and there was 1 case of nonunion, 1 case of possible nonunion, 2 cases of uncertain nonunion, 33 cases of possible union, 30 cases of strong union, with a bone fusion rate of 94%. These findings suggest that NovaBone materials for repair of bone defect due to limb fractures have good biocompatibility and obtain good clinical effect.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Bone Transplantation, Fractures, Bone, Biocompatible Materials

CLC Number:

R318

Du Si-chuang, Yang Jing-chun. NovaBone for repair of limb fractures: its effect on bone graft fusion[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(38): 6121-6125.

Figures/Tables 2

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