Histological changes of pure titanium micro-implant under inflammatory stimulation and orthodontic force as well as bone remodeling

doi:10.3969/j.issn.2095-4344.2015.38.005

Abstract

Abstract:

BACKGROUND: Implant stability is mainly influenced by peri-implant inflammatory stimulation.

OBJECTIVE: To build a beagle model of peri-implantitis under orthodontic force and to observe the bone remodeling of the Beagle dog model.

METHODS: Micro-implants were randomly implanted into the maxillary interradicular region at the center of the mesial and distal roots of bilateral P2, P3, P4 and M1 of Beagle dogs. One side served as a loaded micro-implant with peri-implantitis under 100 g of orthodontic force at 1, 2, 3, 4 weeks of peri-implantitis, and the force lasted for 1 month. After that, the animals were killed to prepare specimens with micro-implants. Bone-to-implant contacts were calculated and histological changes of the bone interface under continuous orthodontic force at different stages of peri-implantitis were observed under light microscope.

RESULTS AND CONCLUSION: There were a large number of inflammatory cells after micro-implants were implanted with silk thread ligation to the cervical part. Over time, inflammatory cells were gradually diffused to the tip of micro-implant, and there were a great quantity of collagenous fibers, osteocytes and active bone remodeling. When the inflammation was diffused to the tip of micro-implant after 2 weeks of peri-implantitis, woven bones
composed of newly formed trabeculae appeared, and imflammatory cells dispersed. The medullary cavity was irregular after collagen fibrils absorption, and there were 3-4 layers of osteoblasts in the bone lacunae, with active bone formation. These findings indicate that the Beagle model of pure titanium peri-implantitis under orthodontic force was successfully built in the experiment, and bone formation became active at 2 weeks after modeling.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Tissue Engineering;, Models, Animal, Inflammation, Osteoblasts

CLC Number:

R318

Zhang Xiao-ge, Tang Tian, Zhao Zhi-he, Ding Yin. Histological changes of pure titanium micro-implant under inflammatory stimulation and orthodontic force as well as bone remodeling[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(38): 6092-6097.

Figures/Tables 2

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