Bionic biphasic ceramic bioactive bone for segmental bone defects

doi:10.3969/j.issn.2095-4344.2015.25.004

Abstract

Abstract:

BACKGROUND: The bioceramics has the ideal pore size, high porosity and the through-hole rate, can provide the ideal physiological activity space for the bone cell repair, and can obviously improve bone conduction.
OBJECTIVE: To explore the bone conduction and bone induction in the repair of bone defects in the stage of bone defect of bionic biphasic ceramic bioactive bone.
METHODS: A total of 20 New Zealand white rabbits were randomly divided into bioactive glass and biomimetic biphasic ceramic bioactive bone groups, and were used to construct the animal bone damage model. They were given the repair with bioactive glass and biomimetic biphasic ceramic bioactive bone.
RESULTS AND CONCLUSION: At 4 weeks after model establishment, scanning electron microscopy demonstrated that dense periosteal tissue was observed in the biomimetic biphasic ceramic bioactive bone group. At 8 weeks, dense combination was found, and no obvious fissure existed. At 12 weeks, complete bone demarcation blurred, showing a natural transition. Moreover, the binding site was very dense. There were a large number of new bone tissues, bone trabecula was regular and connected to a piece. The bone material has been largely degraded. Bone defects were repaired completely. The bone density was close to normal bone. At 8 weeks, in the bioactive glass group, the binding site presented obvious fissure. At 12 weeks, the fissure had been connected, but the binding was not tight as compared with the bionic biphasic ceramic biologic active bone group. The bone defect got preliminary repair. A small number of new bone formed trabecular bone, but could not connect or traverse. There was no recanalization of the marrow cavity. A few continuous bone callus traversed the broken end. These data demonstrate that bionic biphasic ceramic bioactive bone has good bone conduction, bone induction and biocompatibility in the repair of segmental bone defects.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Ceramics, Glass, Biodegradation, Environmental, Bony Callus

CLC Number:

R318

Duan Ning, Zhang Wen-tao, Cheng Hui-guang, Jiao Ning, Han Shao-feng. Bionic biphasic ceramic bioactive bone for segmental bone defects [J]. Chinese Journal of Tissue Engineering Research, 2015, 19(25): 3952-3956.

Figures/Tables 1

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