Effects of aerobic exercise and bone marrow stem cells mobilization on hemodynamics and electrocardiogram of myocardial infarction rats

doi:10.3969/j.issn.2095-4344.2015.19.002

Abstract

Abstract:

BACKGROUND: The electrocardiogram and hemodynamics are effective indicators for evaluation of cardiac function. It has been confirmed that aerobic exercise or bone marrow stem cell mobilization exert good effects on the electrocardiogram and hemodynamics of myocardial infarction animals, and their combination effects have not been reported.
OBJECTIVE: To investigate the effects of aerobic exercise combined with bone marrow stem cell mobilization on the electrocardiogram and hemodynamics of myocardial ischemia aniamals.
METHODS: Ligation of the rat left anterior descending coronary artery was done to make acute myocardial infarction models. Then, rats were divided into aerobic exercise, cell mobilization and combination group (aerobic
exercise+cell mobilization). At 1 week after modeling, rats in the aerobic exercise group and combination group were subject to aerobic exercise in electric treadmill, 5 days per week, totally 8 weeks. At 3 hours of modeling, the rats in the cell mobilization group and combination group were given subcutaneously normal saline-diluted recombinant human granulocyte colony stimulating factor, 10 μg/(kg • d), continuously for 5 days. After 8 weeks, electrocardiogram and part of hemodynamic indexes were detected for evaluation of cardiac function. RESULTS AND CONCLUSION: In rats with myocardial infarction, left ventricular systolic pressure and ±dp/dtmax were reduced significantly, but the left ventricular end diastolic pressure was increased, indicating cardiac insufficiency. An increase in left ventricular systolic pressure and ±dp/dtmax was found in the aerobic exercise and cell mobilization groups, but the left ventricular end diastolic pressure was decreased, indicating that both the aerobic exercise and bone marrow stem cell mobilization could improve the myocardial contraction and diastolic function. Rats in the combination group exhibited similar assessment indicators to normal control rats, indicating the combination of the aerobic exercise and bone marrow stem cell mobilization can strongly enhance the performance of myocardial contraction and myocardial systolic/diastolic functions are both improved significantly.

Key words: Bone Marrow Cells, Motion, Granulocyte Colony-Stimulating Factor, Myocardial Infarction, Hemodynamics

CLC Number:

R394.2

Lv Zhi-wei. Effects of aerobic exercise and bone marrow stem cells mobilization on hemodynamics and electrocardiogram of myocardial infarction rats[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(19): 2959-2964.

Figures/Tables 3

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