Correlation of trace elements and bone fusion surrounding hip prosthesis

doi:10.3969/j.issn.2095-4344.2015.17.010

Abstract

Abstract:

BACKGROUND: The prosthesis fusion rate after total hip replacement is closely related to the reconstruction process of bone, which is affected by the factors around the implant of patient. Trace elements are strongly associated with the ossification. Thus, the content of trace elements in proximal femur may affect the bone fusion and survival rate of the prosthesis.

OBJECTIVE: To analyze the correlation of trace elements and bone fusion surrounding the prosthesis in proximal femur.

METHODS: Bone samples were obtained from the discarded metaphysis region of the proximal femur in 24 patients with primary total hip replacement. Trace element (calcium, magnesium, zinc, parathyroid hormone, activated vitamin D3) contents were detected after vitro cell culture. Bone mineral density was tested surrounding the prosthesis at 1 week, 3 and 6 months after replacement by dual energy X-ray absorption method with a bone density meter. The difference in trace elements was compared in patients at different ages and different genders. The correlation between above five kinds of trace elements and bone mineral density was analyzed.

RESULTS AND CONCLUSION: No significant difference in trace element contents was detected in different age groups and different gender groups (P > 0.05). Zinc content was positively correlated with parathyroid hormone and magnesium contents (P < 0.05). Zinc was positively associated with bone mineral density in the region 7 (P < 0.05). The further studies concerning the trace elements in proximal femur can be used to predict and intervene in the longevity of hip prosthesis.

中国组织工程研究杂志出版内容重点：人工关节；骨植入物；脊柱；骨折；内固定；数字化骨科；组织工程

全文链接：

Key words: Arthroplasty, Replacement, Hip, Zinc, Bone Density

CLC Number:

R318

Fu Xiao-dong, Wang Wei-li, Shen Yi, Li Xiao-miao. Correlation of trace elements and bone fusion surrounding hip prosthesis[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(17): 2677-2682.

Figures/Tables 3

References

[1]Caton JH, Prudhon JL, Ferreira A, et al. A comparative and retrospective study of three hundred and twenty primary Charnley type hip replacements with a minimum follow up of ten years to assess wether a dual mobility cup has a decreased dislocation risk. Int Orthop. 2014; 38(6): 1125-1129.
[2]Nakashima Y, Sato T, Yamamoto T, et al. Results at a minimum of 10 years of follow-up for AMS and PerFix HA-coated cementless total hip arthroplasty: impact of cross-linked polyethylene on implant longevity. J Orthop Sci. 2013;18(6):962-968.
[3]Landor I, Vavrík P, Jahoda D, et al. Long-term experience with the combined ARBOND hydroxyapatite coating in implant osteointegration. Acta Chir Orthop Traumatol Cech. 2009; 76(3): 172-178.
[4]Bidwell JP, Alvarez MB, Hood M Jr, et al. Functional impairment of bone formation in the pathogenesis of osteoporosis: the bone marrow regenerative competence. Curr Osteoporos Rep. 2013;11(2):117-125.
[5]Stroncek DF, Sabatino M, Ren J, et al. Establishing a bone marrow stromal cell transplant program at the National Institutes of Health Clinical Center. Tissue Eng Part B Rev. 2014;20(3) :200-205.
[6]沈奕,李晓淼,傅晓东,等.股骨近端Stro-1+细胞与骨形态发生蛋白及其受体的相关性[J].中国组织工程研究, 2012,16(45): 8380-8384.
[7]Zofková I, Nemcikova P, Matucha P. Trace elements and bone health. Clin Chem Lab Med. 2013;51(8):1555-1561
[8]Vignon E, Valat JP, Rossignol M, et al. Osteoarthritis of the knee and hip and activity: a systematic international review and synthesis (OASIS).Joint Bone Spine. 2006;73(4): 442-455.
[9]Caviglia HA, Osorio PQ, Comando D. Classification and diagnosis of intracapsular fractures of the proximal femur. Clin Orthop Relat Res. 2002;(399):17-27.
[10]柳向东,柴冈,李东,等,成人骨髓间充质干细胞的体外培养和表型鉴定[J].上海第二医科大学学报,2004,4(24):300-301.
[11]Semenowicz J, Mroczka A, Kajzer A, et al. Total hip arthroplasty using cementless avantage cup in patients with risk of hip prosthesis instability. Ortop Traumatol Rehabil. 2014;16(3):253-263.
[12]Gallo J, Vaculova J, Goodman SB, et al. Contributions of human tissue analysis to understanding the mechanisms of loosening and osteolysis in total hipreplacement. Acta Biomater. 2014;10(6):2354-2366.
[13]Cappariello A, Maurizi A, Veeriah V, et al. The Great Beauty of the osteoclast. Arch Biochem Biophys. 2014;558:70-78.
[14]Zaidi M, Moonga BS, Huang CL.Calcium sensing and cell signaling processes in the local regulation of osteoclastic bone resorption. Biol Rev Camb Philos Soc. 2004;79(1): 79-100.
[15]Rocque BG, Kelly MP, Miller JH, et al. Bone morphogenetic protein-associated complications in pediatric spinal fusion in the early postoperative period: an analysis of 4658 patients and review of the literature.J Neurosurg Pediatr. 2014;14(6): 635-643.
[16]Carreira AC, Alves GG, Zambuzzi WF, et al. Bone Morphogenetic Proteins: structure, biological function and therapeutic applications. Arch Biochem Biophys. 2014;561: 64-73.
[17]Marini JC, Reich A, Smith SM. Osteogenesis imperfecta due to mutations in non-collagenous genes: lessons in the biology of bone formation. Curr Opin Pediatr. 2014;26(4):500-507.
[18]赵益峰,王海滨,孟纯阳,等.节段性骨缺损修复过程中几种微量元素含量的研究[J].实用骨科杂志, 2010,16(2):113-117.
[19]Anné J, Edwards NP, Wogelius RA, et al. Synchrotron imaging reveals bone healing and remodelling strategies in extinct and extant vertebrates. J R Soc Interface. 2014;11(96): 20140277.
[20]Engh CA, Mcauley JP, Sychterz CJ, et al. The accuracy and reproducibility of radiographic assessment of stresss-shielding. J Bone Joint Surg (Am). 2000; 82(10): 1414-1420.
[21]Weinans H, Sumner DR, Igloria R, et al. Sensitivity of periprosthetic stress- shielding to load and the bone density-modulus relationship in subject-specific finite element models. J Biomech.2000; 33(7):809-817.
[22]Cohen B, Rushton N. Accuracy of DEXA measurement of bone mineral density after total hip arthroplasty. J Bone Joint Surg Br.1995;77(3):479-483.
[23]Hasegawa T, Hongo H, Sasaki M, et al. Biological function of bone cells on the PTH-driven anabolic effect. Clin Calcium. 2012;22(3):373-379.
[24]Aslan D, Andersen MD, Gede LB, et al. Mechanisms for the bone anabolic effect of parathyroid hormone treatment in humans. Scand J Clin Lab Invest. 2012;72(1):14-22.
[25]Kurabayashi M. Bone and calcium update; diagnosis and therapy of bone metabolism disease update. Calcification of atherosclerotic plaques: mechanism and clinical significance. Clin Calcium. 2011;21(12):43-50.
[26]Goltzman D, Hendy GN, White JH. Vitamin D and its receptor during late development. Biochim Biophys Acta. 2015;1849(2):171-180.
[27]Calvo MS, Tucker KL.Is phosphorus intake that exceeds dietary requirements a risk factor in bone health? Ann N Y Acad Sci. 2013;1301:29-35.
[28]Takeda E, Yamamoto H, Yamanaka-Okumura H, et al. Increasing dietary phosphorus intake from food additives: potential for negative impact on bone health. Adv Nutr. 2014; 5(1):92-97.
[29]Calvo MS, Moshfegh AJ, Tucker KL. Assessing the health impact of phosphorus in the food supply: issues and considerations. Adv Nutr. 2014;5(1):104-113.
[30]Cândido FG, Bressan J. Vitamin D: link between osteoporosis, obesity, and diabetes? Int J Mol Sci. 2014;15(4):6569-6591.
[31]Cranney A, Horsley T, O'Donnell S, et al. Effectiveness and safety of vitamin D in relation to bone health. Evid Rep Technol Assess (Full Rep). 2007;(158): 235.
[32]Chung M, Balk EM, Brendel M, et al. Vitamin D and calcium: a systematic review of health outcomes. Evid Rep Technol Assess (Full Rep). 2009;(183):420.
[33]Lani A, Kourkoumelis N, Baliouskas G, et al. The effect of calcium and vitamin D supplementation on osteoporotic rabbit bones studied by vibrational spectroscopy. J Biol Phys. 2014.
[34]Kemi VE, Kärkkäinen MU, Karp HJ, et al. Increased calcium intake does not completely counteract the effects of increased phosphorus intake on bone: an acute dose-response study in healthy females. Br J Nutr. 2008;99(4):832-839.
[35]Gilaberte Y, Aguilera J, Carrascosa JM, et al. Vitamin D: evidence and controversies. Actas Dermosifiliogr. 2011; 102(8): 572-588.
[36]Souberbielle JC, Maruani G, Courbebaisse M. Metabolism and main effects of vitamin D. Presse Med. 2013;42(10): 1343-1350.
[37]Leccia MT. Skin, sun exposure and vitamin D: facts and controversies. Ann Dermatol Venereol. 2013;140(3):176-182.
[38]Frost HM. From Wolff's law to the Utah paradigm: insights about bone physiology and its clinical applications. Anat Rec. 2001;262(4):398-419.
[39]Aldinger PR, Sabo D, Pritsch M, et al. Pattern of periprosthetic bone remodeling around stable uncemented tapered hip stems: a prospective 84-month follow-up study and a median 156-month cross-sectional study with DXA. Calcif Tissue Int. 2003;73(2):115-121.
[40]Venesmaa PK, Kröger HP, Miettinen HJ, et al. Monitoring of periprosthetic BMD after uncemented total hip arthroplasty with dual-energy X-ray absorptiometry--a 3-year follow-up study. J Bone Miner Res. 2001;16(6):1056-1061.