Human lung adenocarcinoma stem cell phenotypes and patient’s prognosis

doi:10.3969/j.issn.2095-4344.2015.10.009

Abstract

Abstract:

BACKGROUND: Lung adenocarcinoma stem cells are a very important marker for diagnosis of lung adenocarcinoma.

OBJECTIVE: To investigate the relationship between human lung adenocarcinoma stem cell phenotypes and patient’s prognosis.

METHODS: From February 2010 to January 2013, 48 patients with lung adenocarcinoma admitted in the First Affiliated Hospital of Xinjiang Medical University were enrolled. Lung adenocarcinoma cancer stem cell phenotypes were detected with immunofluorescence method, and the relationship of different phenotypes and clinical characteristics with patient’s prognosis was compared.

RESULTS AND CONCLUSION: SP-C and CCSP expression was observed in the lung adenocarcinoma tissues of 48 cases, possessing the phenotypic characteristics of bronchioloalveolar stem cells. Of the 48 patients, OCT4 was positive in 34 cases (OCT4⁺ group) and negative in 14 cases (OCT4^- group). There was no difference between the two groups in terms of patient’s age, gender, smoking history and tumor stage (P > 0.05). There were 23 cases (68%) in the OCT4⁺ group with cancer cell metastasis, which was significantly higher than that in OCT4^- group (21%; P > 0.05). In the aspects of patient’s age, gender, smoking history, staging and cancer metastasis and other clinical pathological stratification, the 2-year survival rate in the OCT4^- group were generally higher than that in the OCT4⁺ group, and there was a significant difference in the survival curves of two groups (P < 0.05). Human lung adenocarcinoma stem cells have the phenotypic characteristics of bronchioloalveolar stem cells, and meanwhile, if the cells are positive for OCT4, patient’s prognosis is poor and associated with lung adenocarcinoma metastasis.

中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

全文链接：

Key words: Neoplastic Stem Cells, Adenocarcinoma, Lung Neoplasms

CLC Number:

R394.2

Maierdan Sailimu, Alidan Erkin, Jin Zhong, He Tie-han. Human lung adenocarcinoma stem cell phenotypes and patient’s prognosis[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(10): 1523-1527.

Figures/Tables 4

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