Correlation between estrogen receptor gene polymorphism and bone mineral density in elderly women

doi:10.3969/j.issn.2095-4344.2015.02.004

Abstract

Abstract:

BACKGROUND: Estrogen receptor α gene polymorphisms is certainly associated with osteoporosis, but there is still questionable for the study of risk genotypes.
OBJECTIVE: To analyze the correlation between estrogen receptor gene polymorphism and bone mineral density in elderly women.
METHODS: Totally 120 healthy elderly women were enrolled to extract the whole blood genomic DNA that was digested using Pvu II and Xba I, the distribution and frequency of genotypes were analyzed. Meanwhile, dual-energy X-ray absorptiometry measurements of bone mineral density with the femoral neck, greater trochanter and Ward’s triangle and were done.
RESULTS AND CONCLUSION: Xba I digested genotypes included the XX in 6 cases, Xx in 78 cases, xx in 36 cases; Pvu II digested genotypes included the PP in 32 cases, Pp in 50 cases, pp in 38 cases. The age, menopause age and body mass index showed no differences among the different genotypes of elderly women (P > 0.05). The bone mineral density values in the trochanter and Ward’s triangle at Pvu II digested PP genotype were significantly greater than those at Pp and pp genotypes (P < 0.05); while no significant differences were found in the bone mineral density values at different Xba I digested genotypes in elderly women (P > 0.05). These findings suggest that estrogen receptor gene polymorphism has certain correlation with the bone mineral density in elderly women, P alleles has certain effect to maintain the bone mineral density of the trochanter and Ward’s triangle in elderly women.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

全文链接：

Key words: Receptors, Estrogen, Genes, Bone density, Osteoporosis, Aged

CLC Number:

R318

Wang Zeng-rong. Correlation between estrogen receptor gene polymorphism and bone mineral density in elderly women[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(2): 182-186.

Figures/Tables 2

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