Correlation between the severity of knee osteoarthritis and levels of chemerin in serum and synovia

doi:10.3969/j.issn.2095-4344.2015.02.003

Abstract

Abstract:

BACKGROUND: Studies have found that after stimulation, chemerin can further amplify the inflammatory signal, resulting in the release of inflammatory factors and matrix metalloproteinases. It indicates that chemerin may serve as an important regulator of cartilage metabolism, and plays an important role in the pathogenesis of osteoarthritis.
OBJECTIVE: To explore the correlation between level of chemerin in synovia and serum and severity of knee osteoarthritis.
METHODS: Eighty patients with knee osteoarthritis were enrolled in the study. Knee osteoarthritis grading was evaluated according to the Kellgren-Lawrence classification. Chemerin levels in synovia and serum were examined with enzyme-linked immunosorbent assay.
RESULTS AND CONCLUSION: The level of chemerin in synovia and serum in patients with knee osteoarthritis were positively correlated with the Kellgren-Lawrence classification (r=0.981, P < 0.001; r=0.901, P < 0.001). And there was a positive correlation between the level of chemerin in synovia and in serum (r=0.596, P < 0.01). Experimental findings suggest that the levels of chemerin in synovial fluid and serum that are positively correlated with the Kellgren-Lawrence classification can be used as a reference biomarker of severity of knee osteoarthritis.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

全文链接：

Key words: Knee Osteoarthritis, Cytokines, Enzyme-Linked Immunosorbent Assay

CLC Number:

R318

Duan Guo-qing, Ren Chun-feng . Correlation between the severity of knee osteoarthritis and levels of chemerin in serum and synovia[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(2): 177-181.

Figures/Tables 2

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