Umbilical cord blood stem cell transplantation influences the endothelium-dependent vasodilation in type 2 diabetic patients with lower extremity vascular disease

doi:10.3969/j.issn.2095-4344.2014.50.011

Abstract

Abstract:

BACKGROUND: Studies have shown that under certain conditions stem cells can be induced to differentiate into vascular endothelial cells, promoting local angiogenesis, generating the new capillary network, and enriching the collateral circulation, so as to improve lower limb ischemia.
OBJECTIVE: To explore the effects of umbilical cord blood stem cell transplantation on endothelium-dependent vasodilation of type 2 diabetic patients with lower extremity vascular disease.
METHODS: Totally 100 type 2 diabetic patients with lower extremity vascular disease were enrolled and divided into two groups: experimental group (n=60) and control group (n=40). The experimental group adopted the intravenous injection of umbilical cord blood stem cells, while the control group was subject to normal saline infusion. After 4 weeks, basic indexes and endothelium-dependent vasodilation were compared between two groups.
RESULTS AND CONCLUSION: In the experimental group, fasting blood glucose, 2-hour postprandial blood glucose, glycosylated hemoglobin, cholesterol, triglyceride levels were significantly reduced (P < 0.05), while fasting insulin, 2-hour postprandial insulin, vascular endothelial dilation function were significantly increased after treatment (P < 0.05). In the control group, there were no differences in fasting blood glucose, 2-hour postprandial blood glucose, glycosylated hemoglobin, cholesterol, triglyceride levels before and after treatment (P > 0.05). These findings indicate that umbilical cord blood stem cell transplantation can improve the endothelial function and promote the collateral circulation in type 2 diabetic patients with vascular lesions of lower extremities, thereby to avoid the occurrence of diabetic foot.

中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

全文链接：

Key words: cord blood stem cell transplantation, diabetes mellitus, type 2, diabetic angiopathies, vasodilation

CLC Number:

R394.2

Li Cui-fang, Yao Yuan. Umbilical cord blood stem cell transplantation influences the endothelium-dependent vasodilation in type 2 diabetic patients with lower extremity vascular disease[J]. Chinese Journal of Tissue Engineering Research, 2014, 18(50): 8098-8102.

Figures/Tables 1

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