Dexamethason with sodium hyaluronate for treatment of traumatic arthritis: a randomized controlled trial

doi:10.3969/j.issn.2095-4344.2014.39.013

Abstract

Abstract:

BACKGROUND: Intra-articular injection of sodium hyaluronate or dexamethasone can relieve pain and increase range of motion after traumatic arthritis.
OBJECTIVE: To observe the effect of dexamethasone combined with sodium hyaluronate on traumatic arthritis of rat knees.
METHODS: Forty-eight Sprague-Dawley rats were randomly divided into four groups. The anterior ligament of the left knee was resected and the medial meniscus was removed to establish models of traumatic arthritis in all the rats. After 3 weeks, the four groups were respectively injected dexamethasone+sodium hyaluronate (combined group), dexamethasone, sodium hyaluronate, and nothing (control group). After 4, 8, 12 weeks of injection, the samples were obtained for gross observation, anteroposterior and lateral X-ray films and hematoxylin-eosin staining.
RESULTS AND CONCLUSION: At 12 weeks after injection, X-ray films showed that there was no stenosis in the combined group, mild stenosis in the dexamethasone and sodium hyaluronate groups, and obvious stenosis in the control group (indicating severe osteoarthritis); hematoxylin-eosin staining exhibited the fibrous cartilage-like tissue grew well in the combined group, varying degrees of proliferation of fibrous cartilage-like cells were visible in the dexamethasone and sodium hyaluronate groups, and there was a small amount of fibrosis in the control group. These findings suggest that the combination of dexamethasone and sodium hyaluronate can improve the cartilage repair and restore the joint function.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

全文链接：

Key words: hyaluronic acid, dexamethasone, arthritis

CLC Number:

R318

Wang Fu-yong, Gu Jian-hua, Zhu Yan-hui, Wang Xiang, Tao Hai-rong, Liu Yong-zhang. Dexamethason with sodium hyaluronate for treatment of traumatic arthritis: a randomized controlled trial[J]. Chinese Journal of Tissue Engineering Research, 2014, 18(39): 6304-6308.

Figures/Tables 4

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