Safety analysis of umbilical cord blood stem cell transplantation combined with nerve growth factor in the treatment of cerebral palsy in children

doi:10.3969/j.issn.2095-4344.2014.28.027

Abstract

Abstract:

BACKGROUND: Umbilical cord blood stem cell transplantation combined with nerve growth factor in the treatment of children with cerebral palsy is a clinical hotspot.
OBJECTIVE: To analyze the efficacy and safety of umbilical cord blood stem cell transplantation combined with nerve growth factor in the treatment of cerebral palsy in children.
METHODS: A total of 80 children with cerebral palsy admitted at the Department of Pediatrics, Hongqiao Hospital of Tianjin, China from 2011 November to 2013 February were enrolled, and according to therapeutic methods, they were divided into experimental group (n=40; treated with umbilical cord blood stem cell transplantation combined with nerve growth factor) and control group (n=40; treated with nerve growth factor alone).
RESULTS AND CONCLUSION: After treatment, scores on comprehensive function assessment scale and gross motor function measure scale were significantly increased in the two groups (P < 0.05), while white cell count, neutrophil fraction, and levels of total bilirubin, alanine aminotransferase and aspartate aminotransferase were also increased (P < 0.05). Moreover, the experimental group showed a better outcome than the control group after treatment (P < 0.05). All of the patients had no serious adverse reactions. Umbilical cord blood stem cell transplantation combined with nerve growth factor has dramatic curative effects in children with severe cerebral palsy significant curative effect, with high safety.

中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

全文链接：

Key words: cerebral palsy, cord blood stem cell transplantation, nerve growth factor, comparative effectiveness research

CLC Number:

R394.2

Li Ying. Safety analysis of umbilical cord blood stem cell transplantation combined with nerve growth factor in the treatment of cerebral palsy in children[J]. Chinese Journal of Tissue Engineering Research, 2014, 18(28): 4588-4592.

Figures/Tables 3

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