Production and functional testing of polyurethane valve of the pediatric Luo-Ye pump

doi:10.3969/j.issn.2095-4344.2013.31.005

Abstract

Abstract:

BACKGROUND: The mechanical valves used in the adult Luo-Ye pump have a large size and great destruction to blood, which are not suitable for infant ventricular assist pump. Therefore, designing and producing a high molecular valve with small size and low incidence of thrombosis is a research hotspot.
OBJECTIVE: To design and produce a valve of 20 mL infant Luo-Ye pump, and to test its basic functions and fatigue properties.
METHODS: The size and shape of valve was designed with MASTERCAM software, polyurethane valve was obtained through producing the valve model and plastic injection; the static leakage, pressure drop and fatigue resistance of polyurethane valve were tested according to the ISO5840 requirements.
RESULTS AND CONCLUSION: The polyurethane trefoil valve was produced, but the failure rate of plastic injection was high; the basic function of the trefoil valve met the ISO5840 requirements bascially; after continuously operated 1.0×107 times, stroke volume of 20 mL Luo-Ye pump was changed 5.2%, and two polyurethane valves and valve leaflets did not change and damage. Polyurethane trefoil valve was designed and produced successfully; polyurethane valves could meet the needs of 20 mL Luo-Ye pump, which already have the ability to clinical trials.

Key words: organ transplantation, heart-lung transplantation, ventricular assist device, Luo-Ye pump, polyurethane, trefoil valve, fatigue resistance, cardiac device, National Natural Science Foundation of China

CLC Number:

R318

Wu Yue-heng, Huang Huan-lei, Fan Rui-xin, Qi Zhou-cuo, Yao Li-ming, Wu Chang-li, Lu Ping-lan, Cheng An-heng, Xiao Xue-jun. Production and functional testing of polyurethane valve of the pediatric Luo-Ye pump[J]. Chinese Journal of Tissue Engineering Research, doi: 10.3969/j.issn.2095-4344.2013.31.005.

Figures/Tables 3

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