Association between SLC30A8 gene polymorphisms and diabetes mellitus after
renal transplantation

doi:10.3969/j.issn.2095-4344.2013.31.006

Abstract

Abstract:

BACKGROUND: Previous studies have found that the susceptibility genes of adiponectin gene and calpain 10 gene of type 2 diabetes are closely related with the incidence of diabetes in Chinese renal transplantation patients. So, are other susceptibility genes of type 2 diabetes also associated with posttransplantation diabetes mellitus? 　
OBJECTIVE: To investigate the association between the zinc transporter solute carrier family 30 member 8 (SLC30A8) gene polymorphism and the posttransplantation diabetes mellitus.
METHODS: A total of 97 patients with posttransplantation diabetes mellitus and 301 patents without posttransplantation diabetes mellitus (control group) were selected, and then the SLC30A8 gene rs13266634 genotype was detected with real-time PCR method. The association between gene polymorphism and posttransplantation diabetes mellitus was analyzed with Logistic regression test.
RESULTS AND CONCLUSION: There were significant differences in allele frequencies and genotype distributions of rs13266634 between the patients with and without posttransplantation diabetes mellitus (P < 0.05). After adjustments of age, sex, body weight and body mass index, the incidence of posttransplantation diabetes mellitus of the CC genotype patients was 2.108 times to that of the TT genotype patients (odds ratio=2.108, 95% confidence interval: 1.075-4.131, P=0.044); and the incidence of posttransplantation diabetes mellitus of the CC+CT genotype patients was 1.862 times to that of the TT genotype patients (odds ratio=1.862, 95% confidence interval: 1.049-3.306, P=0.034). The results suggest that the C-allele in rs13266634 of SLC30A8 gene is the independent risk factor of posttransplantation diabetes mellitus.

Key words: organ transplantation, renal transplantation, posttransplantation diabetes mellitus, SLC30A8 gene, rs13266634, single nucleotide polymorphism, risk factor, allele, diabetes, provincial grants-supported paper

CLC Number:

R318

Yu Ai-rong, Fan Xing, Liu Hui-ming, Xin Hua-wen, Wu Xiao-chun. Association between SLC30A8 gene polymorphisms and diabetes mellitus after
renal transplantation[J]. Chinese Journal of Tissue Engineering Research, doi: 10.3969/j.issn.2095-4344.2013.31.006.

Figures/Tables 6

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