Abstract:

BACKGROUND: There is a growing clinical interest in aspartate aminotransferase (AST) and alanine aminotransferase (ALT) as novel biomarkers of cardiovascular risk factors.
OBJECTIVE: To investigate the relationship between the ratio of AST/ALT and severity of coronary atherosclerosis in a multi-ethnic population.
METHODS: Totally 730 adult patients, including 455 subjects of Han nationality, 126 of Uygur nationality, 63 of Kazakh nationality, 51 of Hui nationality, and 35 of other nationalities, who underwent coronary angiography for suspected or known coronary atherosclerosis were enrolled in the present study. And, the severity of coronary atherosclerosis was defined by the Gensini score. Relationship of the ratio of AST/ALT with the severity of coronary atherosclerosis was investigated.
RESULTS AND CONCLUSION: A significant difference in the level of AST/ALT was not found among the various ethnic groups. Age, gender, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, fasting blood glucose, ALT, AST, and AST/ALT differed significantly among the subjects in the Gensini score quartile. Spearman correlation analyses indicated that the Gensini score was significantly positively associated with age, low-density lipoprotein cholesterol, fasting blood glucose, AST, ALT and AST/ALT, but negatively associated with high-density lipoprotein cholesterol. The AST/ALT was significantly associated with the severity of coronary atherosclerosis in the multi-ethnic population.

Key words: tissue construction, clinical practice of tissue construction, aspartate aminotransferase, alanine aminotransferase, aspartate aminotransferase/alanine aminotransferase, coronary artery disease, Gensini scoring, age, gender, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, blood sugar, the National Natural Science Foundation of China