Changes in bone remodeling-related factors under estrogen and tensile stress

doi:10.3969/j.issn.2095-4344.2013.07.001

Abstract

Abstract:

BACKGROUND: Alveolar bone is one of the most active areas in bone metabolism, and it is liable to be affected by estrogen in orthodontic treatment for female patients.
OBJECTIVE: To investigate the effect of estrogen on receptor activator of nuclear factor kappa B ligand and osteoprotegerin secreted by human periodontal ligament fibroblasts under mechanical tensile stress.
METHODS: Human periodontal ligament fibroblasts were subjected to certain tensile stress loaded by four-point bending strain system after stimulated by different concentrations of estrogen. Reverse transcription-PCR detection was used to investigate the changes of bone reconstruction related factors.
RESULTS AND CONCLUSION: Compared with pure machinery stimulation, human periodontal ligament fibroblasts intervened by estrogen expressed an osteoprotegerin mRNA raised trend, and a decreased trend in the mRNA expression of receptor activator of nuclear factor kappa B ligand. Estrogen can strongly modulate the mRNA expression of osteoprotegerin and receptor activator of nuclear factor kappa B ligand in human periodontal ligament fibroblasts under mechanical tensile stress.

Key words: tissue construction, cartilage tissue construction, periodontal ligament fibroblasts, tensile stress, estrogen, osteoprotegerin, receptor activator of nuclear factor kappa B ligand, bone reconstruction, tissue construction photographs-containing paper

CLC Number:

R318

Peng Wei, Liao Chun-hui, Zhong Xiao-long, Chen Shan. Changes in bone remodeling-related factors under estrogen and tensile stress[J]. Chinese Journal of Tissue Engineering Research, 2013, 17(7): 1141-1145.

Figures/Tables 8

References

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