Comparison of clinical efficacy between orthotopic ileal neobladder and orthotopic sigmoid neobladder in female bladder cancer patients

doi:10.3969/j.issn.2095-4344.2013.05.022

Abstract

Abstract:

BACKGROUND: The orthotopic urinary diversion after radical cystectomy of bladder cancer has good urinary continence. However, there are few reports about the clinical efficacy and follow-up of orthotopic ileal neobladder and orthotopic sigmoid neobladder in female bladder cancer patients.
OBJECTIVE: To compare the clinical efficacy of orthotopic ileal neobladder and orthotopic sigmoid neobladder in female bladder cancer patients.
METHODS: The clinical data of the female patients with bladder cancer who were treated with orthotopic ileal neobladder (ileal group, n=29) and orthotopic sigmoid neobladder (sigmoid group, n=23) from 1996 to 2008 were retrospective analyzed. The intraoperative and postoperative conditions, urodynamics, urinary continence, pouch-related complications of the patients in two groups were compared.
RESULTS AND CONCLUSION: The average follow-up time was 57 months in the ileal group, and 55 months in the sigmoid group. There was no difference in intraoperative blood loss and postoperative urinary continence between two groups, and there were significance differences in operative time, postoperative out-of-bed activity and the orthotopic neobladder’s capacity between two groups (P < 0.05). The early and late pouch-related complication rates in the ileal group were higher than those in the sigmoid group. In the ileal group, tumor recurred in two patients, and no tumor recurred in the sigmoid group. It indicates that orthotopic ileal neobladder and orthotopic sigmoid neobladder in female patients are both safe and effective to achieve satisfactory clinical outcomes.

Key words: organ transplantation, basic experiments of organ transplantation, urinary diversion, ileal neobladder, sigmoid neobladder, urodynamic, urinary continence, women, bladder cancer, efficacy

CLC Number:

R318

Wang Hai-feng, Wang Jian-song, Xu Hong-yi, Shi Yong-fu, Zuo Yi-gang, Yang De-lin. Comparison of clinical efficacy between orthotopic ileal neobladder and orthotopic sigmoid neobladder in female bladder cancer patients[J]. Chinese Journal of Tissue Engineering Research, 2013, 17(5): 907-912.

Figures/Tables 5

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