Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (48): 9069-9073.doi: 10.3969/j.issn.2095-4344.2012.48.027

Previous Articles     Next Articles

Research and mechanism of bacterial biofilm on the surface of orthopedic implants

Wang Yong-qing1, Bi Hong-bin2   

  1. 1Department of Orthopedics, the Fourth Central Hospital of Tianjin, Tianjin 300140, China
    2Tianjin University of Traditional Chinese Medicine, Tianjin 300139, China
  • Received:2012-02-05 Revised:2012-03-10 Online:2012-11-25 Published:2013-03-14
  • Contact: Bi Hong-bin, Studying for master’s degree, Tianjin University of Traditional Chinese Medicine, Tianjin 300139, China abinbhb@126.com
  • About author:Wang Yong-qing☆, Doctor, Chief physician, Professor Doctoral supervisor, Department of Orthopedics, the Fourth Central Hospital of Tianjin, Tianjin 300140, China

PDF

668

Abstract:

BACKGROUND: After the formation of biofilm, drug resistance of bacteria will become strong, but surgical infection, especially the orthopedic implant infection is related to bacterial biofilm on the surface of materials.
OBJECTIVE: To review the mechanism and research progress of the formation, structure, influencing factors, drug-resistant mechanisms, prevention and control measures of bacterial biofilm.
METHODS: The CNKI database and PubMed database from January 1982 to September 2011 were used to search the articles on prevention treatment of bacterial biofilm and the formation of biofilms after postoperative infection of implants. A total of 34 articles were included to review.
RESULTS AND CONCLUSION: The using of antibiotics can effectively remove the bacterial biofilms, and lead to the drug resistance. Changes in the microenvironment of the biofilm, good biocompatibility of implant materials selection and lower bacterial adhesion may be the future direction of anti-infective research.

CLC Number: