Association of polymorphisms of klotho gene with primary osteoporosis in the elderly aging above 60 years old

doi:10.3969/j.issn.2095-4344.1973

Abstract

Abstract:

BACKGROUND: Klotho gene has been shown to be related to various diseases, such as osteoporosis, tumor, atherosclerosis and dyslipidemia.
OBJECTIVE: To further testify the association of polymorphisms of klotho gene with primary osteoporosis in elderly (≥ 60 years old).
METHODS: The study was in accordance with the ethical requirements of Binzhou Medical University Hospital, and the participants signed the informed consents. A total of 609 elderly Han patients were selected
from Medical Examination Center and Division of Geriatrics of Binzhou Medical University Hospital. There were 303 osteoporotic patients, and 306 healthy controls. Genotypes of klotho G395A and F352V polymorphisms were analyzed by multiplex SNaPshot SNP reaction.
RESULTS AND CONCLUSION: (1) The distribution frequency of GG genotype of klotho G395A in the control group was higher than that in the osteoporosis group (P < 0.05). (2) The distribution frequency of GG genotype of klotho G395A in the female osteoporosis group was lower than that in the control group (P < 0.05). (3) According to multivariate logistic regression analysis, the total bilirubin, age and body mass index were risk factors of primary osteoporosis. (4) In summary, the klotho loci G395A and F352V polymorphisms may be not the risk factors of osteoporosis in the Han elderly in this area. Total bilirubin, age and body mass index may be related to osteoporosis.

Key words: klotho gene, elderly, osteoporosis, total bilirubin, bone mineral density

CLC Number:

Ma Qiuhua, Wang Yunwen, Ma Hui, Qi Jie, Zhang Qingtan. Association of polymorphisms of klotho gene with primary osteoporosis in the elderly aging above 60 years old[J]. Chinese Journal of Tissue Engineering Research, 2019, 23(35): 5587-5591.

Figures/Tables 4

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