Finite element analysis and demonstration of scaffold material stacking

doi:10.3969/j.issn.2095-4344.1404

Abstract

Abstract:

BACKGROUND: The uncertainty of repairing results of tissue-engineered cartilage is related to the mechanical behavior of repairing area. The shape, depth and load characteristics of repairing defects will change the mechanical environment of repairing area in varying degrees. Therefore, the appropriate mechanical properties of artificial cartilage can be explored by studying the above parameters.

OBJECTIVE: To analyze the effect of the shape and stacking method of the scaffold material on the mechanical behavior of the repairing area by finite element method.

METHODS: MRI-3D printed silk fibroin/collagen composite scaffolds were used. These scaffolds were cut into circular and rectangular products. Each shape of products were stacked vertically and obliquely to form a three-dimensional entity. ANSYS12.0 and Solid95 units were used for modeling and mesh generation. 10 kPa load (Z=10 mm) was uniformly added to the top of the material. The displacement, stress, and strain distribution of the material were analyzed.

RESULTS AND CONCLUSION: Vertical stacking of circular and rectangular products had regular shapes, with strict symmetry of X and Y axis. Oblique stacking of circular and rectangular products had irregular shapes, which can only meet the symmetry of the X axis, and Y and Z axes had characteristics of ladder. Compared with the vertical stacking, the axial displacement of obliquely stacked products was more obvious, which did not facilitate bone tissue ingrowth. Vertical stacking of circular and rectangular products led to uniform stress distribution, with strict axial symmetry. There was a small area of large strain (stress) region caused by stress concentration in the bottom edge or corner. When circular and rectangular products were obliquely stacked, asymmetries in shape and loads led to nonuniform and ladder-shaped local stress, and there was a large area of strain (stress) region. These results suggest that circular product is preferable over rectangular product, and vertical stacking is conductive to repairing bone tissue compared with oblique stacking.

Key words: silk fibroin/collagen composite scaffold, finite element analysis, scaffold, circular, rectangular, vertical stacking, oblique stacking, three-dimensional

CLC Number:

Sun Kai, Li Ruixin, Li Hao, Li Dong, Li Hui. Finite element analysis and demonstration of scaffold material stacking[J]. Chinese Journal of Tissue Engineering Research, 2019, 23(30): 4787-4792.

Figures/Tables 5

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