Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (23): 4323-4328.doi: 10.3969/j.issn.1673-8225.2012.23.028

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Progress of autologous hematopoietic stem cells transplantation in the treatment of lymphoma

Guo Yi-gang, Feng Xue-lian, Liu Lin   

  1. Department of Hematology, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
  • Received:2011-09-05 Revised:2011-09-05 Online:2012-06-03 Published:2013-11-06
  • Contact: Liu Lin, M.D., Master’s supervisor, Professor, Department of Hematology, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, Sichuan Province, China Liul7776@yahoo.com.cn
  • About author:Guo Yi-gang★, Studying for master’s degree, Department of Hematology, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China youasme@yeah.net

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Abstract:

BACKGROUND: Autologous hematopoietic stem cells transplantation is an effective scheme for treatment of lymphoma.
OBJECTIVE: To summarize the progress of autologous hematopoietic stem cells transplantation in the treatment of lymphoma
METHODS: We retrieved PubMed database, CNKI database, Wanfang database, Vip database, digital journals of Chinese Medical Association and Google network database for articles published from January 1990 to February 2011, which was about autologous hematopoietic stem cells transplantation in the treatment of lymphoma. The key words were “autologous hematopoietic stem cells transplantation, lymphoma”. A total of 371 articles were retrieved and 31 articles were included according to the inclusion criteria.
RESULTS AND CONCLUSION: Hundreds of thousands patients with lymphoma have been cured since autologous hematopoietic stem cells transplantation was developed in 1980s. Before transplantation, the pretreatment scheme from simple high-dose chemotherapy regimen at first evolved into combined with rituximab and isotope-labeled monoclonal antibody; the rituximab developed from a purification medication before pretreatment to an important medication that was used before and after autologous hematopoietic stem cells transplantation for a long time. However, autologous hematopoietic stem cells transplantation, as a backup of hematopoietic system for patients promotes hemopoietic system recovery quickly after pretreatment. With further development, autologous hematopoietic stem cells transplantation will become the important scheme of lymphoma treatments.

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