Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (23): 4310-4315.doi: 10.3969/j.issn.1673-8225.2012.23.026

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Development of adipose-derived stem cells and their transplantation for treatment of cerebral ischemia

Jiang Wei1, Liang Guo-biao2, Liu Min-pei3   

  1. 1Dalian Medical University, Dalian 116027, Liaoning Province, China;
    2Department of Neurosurgery, the General Hospital of Shenyang Military Region, Shenyang 110016, Liaoning Province, China;
    3Military Institute of Neurological Medicine of Chinese PLA, Shenyang 110016, Liaoning Province, China
  • Received:2011-09-01 Revised:2011-10-18 Online:2012-06-03 Published:2013-11-06
  • Contact: Liang Guo-biao, Master’s supervisor, Professor, Chief physician, Department of Neurosurgery, the General Hospital of Shenyang Military Region, Shenyang 110016, Liaoning Province, China liangguobiao6708@163.com
  • About author:Jiang Wei★, Studying for master’s degree, Dalian Medical University, Dalian 116027, Liaoning Province, China doctorjw@163.com

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Abstract:

BACKGROUND: Studies show that transplantation of adipose-derived stem cells (ADSCs) can improve the neurological functions of animals in treatment of cerebral ischemia.
OBJECTIVE: To summarize the literatures on the biological characteristics, differentiation, and applications in ischemic diseases of ADSCs.
METHODS: A computer-based online search of literatures published from January 2005 to December 2010 related to the development of adipose-derived stem cells and their transplantation for treatment of cerebral ischemia was performed in CNKI database and PubMed database using the key words of “adipose-derived stem cells, therapy of transplant, cerebral ischemia”. The documents associated with the development of adipose-derived stem cells and their transplantation for treatment of cerebral ischemia were selected, and those published in 3-5 years or in authoritative journals were preferred in the same field. Totally 152 articles in English and Chinese were obtained in initial retrieval, and 38 of them were chosen to summarize based on inclusion criteria.
RESULTS AND CONCLUSION: ADSCs have many advantages including easy-to-obtain, rich resources, rapid expansion, non-tumorigenesis, low immunogenicity, and non-ethical constraints. Preclinical experiments have demonstrated that transplantation of ADSCs can improve the neurological functions, reduce the region of small cerebral infarction, promote angiogenesis, and express neuron-specific markers. The improvement of neurological functions was proved in experiments with different ways and times of ADSCs transplantation, but the mechanism is still unclear. The treatment of ischemic disease by ADSCs transplantation needs more research to consummate the mechanism.

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