Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (6): 1050-1055.doi: 10.3969/j.issn.1673-8225.2012.06.023

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Neural stem cells transplantation in subacute stage of spinal cord injury: Expression of 5-hydroxytryptamine injured spinal cord  

Ba Ying-chun1, Tang Jian-zhong2, Fan Yan1, Li Zhong-ming1, Wang Jin-de1, Wang Ting-hua3   

  1. 1Department of Human anatomy, Kunming Medical College, Kunming  650500, Yunnan Province, China; 2Department of Hepatology, First People's Hospital of Yunnan Province, Kunming  650032, Yunnan Province, China; 3Institute of Neuroscience, Kunming Medical College, Kunming  650500, Yunnan Province, China
  • Received:2011-08-20 Revised:2011-11-16 Online:2012-02-05 Published:2012-02-05
  • Contact: Wang Ting–hua, Doctor, Professor, Institute of Neuroscience, Kunming Medical College, Kunming 650500, Yunnan Province, China Tinghua_neuron@263.net
  • About author:Ba Ying-chun☆, Doctor, Associate professor, Department of Human anatomy, Kunming Medical College, Kunming 650500, Yunnan Province, China byc71206@yahoo.com.cn

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Abstract:

BACKGROUND: 5-hydroxytryptamine (5-HT) serotonergic fibers are evaluated as one of regenerative indice after spinal cord injury.
OBJECTIVE: To study effects of neural stem cells (NSCs) transplantation on the recovery of the rats injured spinal cord in subacute stage (on the 7th day).
METHODS: The normal adult SD female rats were divided into 3 groups: merely spinal cord transection group, sham operation group (just opened the lamina, but not transected the spinal cord), NSCs transplantation group. NSCs transplantation group was performed on the 7th day after spinal cord transection, the other two groups were not performed with transplantation.
RESULTS AND CONCLUSION: In 1-2 segments above scar of spinal cord, the number of 5-HT positive fibers in NSCs transplantation group was more than that in merely spinal cord transection group. It indicates that NSCs transplantation group in subacute stage can promote the nerve regeneration after spinal cord injury.

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