Abstract:

BACKGROUND: CD34+ cell is a new marker of vascular endothelium, the detection of CD34+ cells level may reflect the changes of endothelial function.
OBJECTIVE: To analyze the relationship between the number of CD34+ cells and the cerebral infarction.
METHODS: A total of 110 subjects were included to review, the subjects were divided into four groups: type 2 diabetes group, acute cerebral infraction group, combination group (n=30) and control group (n=20). Flow cytometry Pro COUNT method was used to measure the number of peripheral blood CD34+ mononuclear cells and analyze the relationship with the risk factors for cerebrovascular disease.
RESULTS AND CONCLUSION: There was significant difference in the number of peripheral blood CD34+ mononuclear cells of four groups (P < 0.05) analyzed by variance. The number of peripheral blood CD34+ mononuclear cells in control group was higher than that in other three groups (P < 0.01), the type 2 diabetes group was higher than acute cerebral infraction group and combination group (P < 0.01). The number of peripheral blood CD34+ mononuclear cells in patients with type 2 diabetes combined with acute cerebral infraction was negative correlated with fasting plasma glucose and systolic blood pressure, and positively correlated with the ratio of high-density lipoprotein cholesterol/low-density lipoprotein cholesterol. It had no relationship with diastolic blood pressure, smoking, cholesterol and triglyceride. CD34+ cells can influence the cerebral infarction development by its risk factors, so the monitoring of CD34+ can be used to prevent the occurrence of acute cerebral infarction in type 2 diabetes patients.