Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (4): 673-678.doi: 10.3969/j.issn.1673-8225.2012.06.024

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Application of antibiotic-loaded bone cement spacer in second-stage revision for infected total hip arthroplasty  

Yan Yun-fei1, Guo Ting2, Zhou Li-wu2, Wang Rui2, Bao Ni-rong2, Cheng Xiu-hong2, Zhao Jian-ning1, 2   

  1. 1Clinical Institute of Nanjing University Medical School, Nanjing  210002, Jiangsu Province, China; 2Department of Orthopedics, Nanjing General Hospital of PLA Nanjing Military Region, Nanjing  210002, Jiangsu Province, China
     
  • Received:2011-08-15 Revised:2011-11-25 Online:2012-01-22 Published:2014-04-04
  • Contact: Zhao Jian-ning, Professor, Chief physician, Doctoral supervisor, Clinical Institute of Nanjing University Medical School, Nanjing 210002, Jiangsu Province, China; Department of Orthopedics, Nanjing General Hospital of PLA Nanjing Military Region, Nanjing 210002, Jiangsu Province, China zhaojianning.0207@163.com
  • About author:Yan Yun-fei★, Studying for master’s degree, Clinical Institute of Nanjing University Medical School, Nanjing 210002, Jiangsu Province, China yanyunfei04@126.com
  • Supported by:

    the National Natural Science Foundation of China, No. 81000792*

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Abstract:

BACKGROUND: Infection is one of the most serious complications of total hip arthroplasty (THA) surgery, although there are many ways can treat the infection, secondary revision procedures is recognized as an effect treatment method.
OBJECTIVE: To retrospectively study the effect of antibiotic-loaded bone cement spacer in second-stage revision for infected THA.
METHODS: Totally 27 hips from 26 cases who infected after THA were treated with two-stage revision using antibiotic-loaded bone cement spacer to instead the position of original prosthesis. During this procedure, a steinmann pin was load in the center of the spacer as scaffold. All the cases were followed up after the surgery and Harris score was evaluated.
RESULTS AND CONCLUSION: Due to improper weight-bearing activities after surgery, the spacer of one case was ruptured, after removal of the bone cement spacer and debridement, the joint was spacious placed. The other 25 cases were all followed up for 1 to 7 years. After surgery, the mean Harris hip score reached 90.2 which improved 61.9 as compared with before operation, and the cure rate was 96.3%. It is indicated that infected THA can be successfully treated by two-stage revision surgery with antibiotic-loaded bone cement spacers, and has the advantage of higher infection control rate and joint function recovery.

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