Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (2): 341-344.doi: 10.3969/j.issn.1673-8225.2012.02.034

Previous Articles     Next Articles

Adenosine monophosphate-activated protein kinase and myofibrillar protein degradation                              
 

Ma Yan-chao1, Zhu Rong2, Li Jun-ping3   

  1. 1College of Physical Education, Luoyang Normal University, Luoyang  471022, Henan Province, China; 2Wenzhou Medical College, Wenzhou  325035,  Zhejiang Province, China; 3Beijing Sport University, Beijing 100084, China
  • Received:2011-05-13 Revised:2011-05-23 Online:2012-01-08 Published:2012-01-08
  • Contact: Li Jun-ping, Doctor, Lecturer, Beijing Sport University, Beijing 100084, China doctorljp@126.com
  • About author:Ma Yan-chao☆, Doctor, Associate professor, College of Physical Education, Luoyang Normal University, Luoyang 471022, Henan Province, China yanchaoma@126.com
  • Supported by:

    a Project of Ministry of Education of China, No. 20091112120002

PDF

346

Abstract:

BACKGROUND: Adenosine monophosphate-activated protein kinase (AMPK) is an intracellular energy sensor in skeletal muscle, which can be activated by exercise. AMPK, widely existing in eucaryotic cells, is the serine/threonine protein kinase.
OBJECTIVE: To review the structure and the function of AMPK, changes of AMPK activity and the influence of AMPK activity on skeletal muscle protein degeneration during exercise.
METHODS: A computer-based online retrieval of China National Knowledge Infrastructure (CNKI), Vip database, http://highwire.stanford.edu and www.ncbi.nlm.nih.gov/pubmed was performed to search papers regarding AMPK and myofibrillar protein degradation. The structure and the function of AMPK, the change of AMPK activity in exercise, and the effect of AMPK activation on myofibrillar protein degradation were retrieved. 
RESULTS AND CONCLUSION: A total of 35 papers were retrieved. This study summarized the structure and the function of AMPK. In the resistance exercise and in the moderate and high intensity cycle exercise, AMPK activity may be increased, and in the low intensity cycle exercise, AMPK activity may not be increased. Activated AMPK may promote the protein degradation.
 

CLC Number: