Abstract:

BACKGROUND: The re-epithelialization process based on keratinocyte is essential for the regeneration of wound stratified epithelium. It is reported that microRNA-210 can negatively regulate the keratinocyte proliferation in murine ischemic wound model, and can block the re-epithelialization process of the wound. It indicates that microRNAs may involve in wound repair by influencing the biological activities of keratinocyte.
OBJECTIVE: To thoroughly understand the effects of microRNAs on the biological activities of keratinocyte; to direct the research strategies on wound healing; and to provide theoretical basis for the prevention and treatment of abnormal wound repair.
METHODS: An online search of PubMed and Embase database (2011-05) was performed using key words of “keratinocyte”, “microRNA” for articles published in English. A total of 59 papers were collected. The irrelevant or repetitive papers were eliminated by screening for the titles and abstracts. A number of 12 papers were retained. These papers were manually retrieved in addition with 30 additional papers and 2 microRNA databases.
RESULTS AND CONCLUSION: MicroRNA can regulate the proliferation, differentiation and migration of keratinocyte. In particularly, it can block the re-epithelialization process of ischemic wound. It is expected to be a possible therapeutic target. But most of the present research is focused on in vitro experiment. It is necessary that the existed findings can be applied in animal model and clinical research.