Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (44): 8221-8224.doi: 10.3969/j.issn.1673-8225.2011.44.014

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Clinical application of salvia miltiorrhiza injection on the treatment of acute and chronic vascular rejection after renal transplantation

Chen Xia1, Cai Xian-an1, Zhou Li-juan2, Cai Teng3   

  1. 1Department of Urology, Zhengzhou Central Hospital, Zhenzhou  450007, Henan Province, China; 2Department of Pharmacy, Zhengzhou Central Hospital, Zhenzhou 450007, Henan Province, China; 3Department of Urology, Medical College of Zhengzhou University, Zhengzhou   450052, Henan Province, China
  • Received:2011-05-27 Revised:2011-07-25 Online:2011-10-29 Published:2011-10-29
  • Contact: Cai Xian-an, Chief physician, Department of Urology, Zhengzhou Central Hospital, Zhenzhou 450007, Henan Province, China
  • About author:Chen Xia, Associate chief physician, Department of Urology, Zhengzhou Central Hospital, Zhenzhou 450007, Henan Province, China cxxx8@126.com

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Abstract:

BACKGROUND: Clinical observation shows that simple use of methylprednisolone (MP) to treatment acute and chronic vascular rejection after renal transplantation cannot obviously improve urine protein and serum creatinine levels and that salvia miltiorrhiza injection combined with MP can promote the functional recovery of transplanted kidney.
OBJECTIVE: To investigate the effects of salvia miltiorrhiza injection on acute and chronic vascular rejection and renal function recovery after renal transplantation. METHODS: 180 cases with acute vascular rejection and 140 cases with chronic vascular rejection after renal transplantation were randomly divided into a control group and a treatment group. The control group patients were simply treated with routine MP for 3 days. The treatment group patients received MP administration for 3 days followed by intravenous administration of salvia miltiorrhiza injection for 15 days.
RESULTS AND CONCLUSION: Compared with pretreatment, the indices of renal function were significantly improved in the control and treatment groups with acute and chronic vascular rejection (P < 0.05). The recovery of renal function was more obvious in the treatment group than in the control group (P < 0.05). Prothrombin time and activated partial thromboplastin time were significantly prolonged in the treatment group than in the control group (P < 0.05). Renal function was obviously improved after salvia miltiorrhiza injection was added based on conventional treatment in patients with acute and chronic vascular rejection after renal transplantation.

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