Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (44): 8225-8228.doi: 10.3969/j.issn.1673-8225.2011.44.015

Previous Articles     Next Articles

Analysis of factors inducing panel reactive antibodies in patients waiting for first kidney transplantation

Wu Jun-jie, Jia Bao-xiang, Tian Ye   

  1. Department of Kidney Transplantation, Beijing Friendship Hospital, Capital Medical University Beijing   100050, China
  • Received:2011-08-05 Revised:2011-08-15 Online:2011-10-29 Published:2011-10-29
  • About author:Wu Jun-jie, Technician in charge, Department of Kidney Transplantation, Beijing Friendship Hospital, Capital Medical University Beijing 100050, China wjj0037@sina.com
  • Supported by:

    Scientific Research Foundation of Beijing Friendship Hospital, No.2009-24*

PDF

352

Abstract:

BACKGROUND: It has been suggested that panel reactive antibodies (PRA) levels are strongly correlated with acute rejection episodes. The positive PRA, either from pre- or post- transplant, is one of the important predictors of renal allograft function and survival.
OBJECTIVE: To characterize the factors inducing PRA sensitivity among uremia patients waiting for first kidney transplantation.
METHODS: PRA tests were performed in 1674 uremia patients waiting for their first kidney transplantation. They were divided into four groups, according to their history of transfusion and pregnancy. Group A: 509 patients with mere transfusion history; group B: 397 patients with mere pregnant history; group C: 235 patients with both transfusion and pregnant history; group D: 533 patients with neither transfusion nor pregnancy history.
RESULTS AND CONCLUSION: PRA positive rate was 17.29% (88/509), 8.31% (33/397), 27.23% (64/235) in group A, group B, and group C, respectively. No PRA positive rate was shown in group D. These findings suggest that the sensitizing effect of pregnancy alone on PRA level is comparatively low and is not increased along with the number of pregnancies. The transfusion factor comes in the second lowest effect. PRA positive rate is statistically significant higher in females in the transfusion group. Group C shows significantly higher PRA level, compared with either group A or group B. The patients with neither transfusion nor pregnancy history generally will not produce PRA.

CLC Number: