Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (44): 8197-8200.doi: 10.3969/j.issn.1673-8225.2011.44.008

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Correlation between red cell nature-immune-adhesion function and T, B lymphocyte immune function in liver transplantation patients during the perioperative period

Wang Xu1, Chen Hong1, Shen Zhong-yang1, Wang Hai-yan2, Song Li-jie2   

  1. 1Institute of Transplantation, 2Department of Laboratory Medicine, General Hospital of Armed Police Forces, Beijing  100039, China
  • Received:2011-05-06 Revised:2011-07-30 Online:2011-10-29 Published:2011-10-29
  • Contact: Chen Hong, Doctor, Chief physician, Institute of Transplantation, General Hospital of Armed Police Forces, Beijing 100039, China
  • About author:Wang Xu★, Master, Physician, Institute of Transplantation, General Hospital of Armed Police Forces, Beijing 100039, China wangxu9272008@ 126.com

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Abstract:

BACKGROUND: Domestic multi-center study data have shown that erythrocyte nature-immune-adhesion function (RNIAF) had been correlated with the degree of liver damage and can be used as a sensitive indicator for evaluating the degree of diseases and the prognosis of liver transplantation, but RNIAF in the field of liver transplantation has been rarely reported.
OBJECTIVE: To investigate the correlation between RNIAF and lymphocyte cell immune function in liver transplantation patients during the perioperative period.
METHODS: Twenty-one patients were studied in terms of erythrocyte C3b receptor (CR1) activity and lymphocyte subsets, and a healthy population was used as controls. Yeast rosette formation test was applied to detect the immunocomplex receptor chaplet. The level of RNIAF and lymphocyte subsets was been analyzed and the correlation between them was also studied.
RESULTS AND CONCLUSION: The RNIAF level in the control group was 25.89±6.12 /200 erythrocytes. The RNIAF level in the control group was 14.35 ± 5.89 /200 erythrocytes, 10.37 ± 3.48 /200 erythrocytes, 18.60 ± 8.36 /200 erythrocytes, 22.85 ± 8.90 / 200 erythrocytes and 29.14 ± 5.00 /200 erythrocytes, respectively before, 1 day, 1 week, 2 weeks and 1 month after liver transplantation. There was a positive correlation between erythrocyte nature-immune-adhesion function and the level of lymphocyte subsets (CD4, CD8, CD4/CD8, B, CD45). Significant difference could be observed in RNIAF level during the perioperative period of liver transplantation instead of lymphocyte subsets. RNIAF is a sensitive indicator for evaluating the degree of liver diseases and prognosis of liver transplantation.

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