Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (44): 8201-8204.doi: 10.3969/j.issn.1673-8225.2011.44.009

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Transplantation of autologous olfactory ensheating cells combined with beta-aescinate sodium for repair of spinal cord transection in rats

Wang Lu, Wang Hang-hui, Liu Bo-feng, Zhao Lin   

  1. Department of Anatomy, Medical College of Yan’an University, Yan’an 716000, Shaaxi Province, China
  • Received:2011-06-19 Revised:2011-07-21 Online:2011-10-29 Published:2011-10-29
  • About author:Wang Lu★, Studying for master’s degree, Associate professor, Department of Anatomy, Medical College of Yan’an University, Yan’an 716000, Shaaxi Province, China Wang Hang-hui★, Master, Associate professor, Department of Anatomy, Medical College of Yan’an University, Yan’an 716000, Shaaxi Province, China Wang Lu and Wang Hang-hui contributed equally to this study
  • Supported by:

    Science Research Foundation of Health Department of Shaanxi Province, No. 2010H25*; the Natural Science Foundation of Shaaxi Province, No. 08JK502*; Science and Technology Plan of Yan’an City, No. 2009KS-22*

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Abstract:

BACKGROUND: Transplantation of olfactory ensheating cells (OECs) can promote axon regeneration and reduce the proliferation of astrocytes in spinal cord injury.
OBJECTIVE: To explore the protective effects and mechanism of transplantation of autologous OECs combined with β-aescinate sodium in spinal cord injury rats. METHODS: Healthy Sprague-Dawley rats were divided into three groups: control, autologous OECs transplantation (OECs), transplantation of autologous OECs combined with β-aescinate sodium (OECs + β-aescinate sodium).
RESULTS AND CONCLUSION: Vasogenic spinal cord edema and matrix metalloproteinase 9 expression were increased, and rat motor function was lost. After transplantation of autologous OECs combined with β-aescinate sodium, spinal cord edema was obviously alleviated, MMP-9 expression was downregulated, rat motor function was recovered. These symptoms were obvious in the OECs + β-aescinate sodium group. Results showed that transplantation of autologous OECs combined with β-aescinate sodium can effectively repair spinal cord injury and show protective effects.

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