Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (15): 2665-2668.doi: 10.3969/j.issn.1673-8225.2011.15.002

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Comparison of vasoactive intestinal polypeptide expression between normal and osteoarthritic cartilages

Chen Xia-guang1, Lei Guang-hua2, Qian Rui1, Xiao Shi-liang1, Cai Xing-jian1, Liu Zhen-yu1   

  1. 1Department of Orthopaedics, People’s Hospital of Ganzhou, Ganzhou  341000, Jiangxi Province, China
    2Department of Orthopaedics, Xiangya Hospital of Central South University, Changsha  410008, Hunan Province, China
  • Received:2010-09-19 Revised:2010-11-27 Online:2011-04-09 Published:2013-11-06
  • About author:Chen Xia-guang★, Master, Physician, Department of Orthopaedics, People’s Hospital of Ganzhou, Ganzhou 341000, Jiangxi Province, China xxiaguang@yahoo.com.cn

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Abstract:

BACKGROUND: The discovery of neuropeptide provides new hope for the treatment of osteoarthritis, however, the relationship between neuropeptide expression and pathogenesis of osteoarthritis or degeneration of articular cartilage remains poorly understood. 
OBJECTIVE: To observe the expression of vasoactive intestinal peptide (VIP) in normal and osteoarthritic chondrocytes, and to explore the correlation between VIP and pathogenesis and progression of osteoarthritis. 
METHODS: Human cartilages were obtained at arthroplasty from 26 patients with osteoarthritis. Meanwhile, articular cartilages were obtained at arthroplasty or amputation for trauma, tumour or infection from 10 patients with no history of arthritis. Then collect 50 cartilage specimens from osteoarthritis and normal joints, all the specimens were grouped according to Mankin pathological score, and the expression and distribution of VIP was detected by immunohistochemical staining. 
RESULTS AND CONCLUSION: VIP positive nerve fibers existed in both normal and osteoarthritic cartilages. The expression of VIP was greater in normal cartilage than that of the osteoarthritic cartilages (P < 0.05). The VIP expression was negative correlated with Mankin pathological scores (r=-0.896, P < 0.05). The findings demonstrated that, low expression of VIP is concerned with pathogenesis and progression of osteoarthritis, which may be the mechanism for pathogenesis and progression of osteoarthritis.

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