Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (11): 2006-2008.doi: 10.3969/j.issn.1673-8225.2011.11.026

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Pathological changes of mouse periodontal tissues following photodynamic therapy

Du Bo1, Jiang Lin2, Liu Ming-fang3, Li Ping-ping1, Lin Ju-hong1   

  1. 1Department of Endodontics, 2Department of Prevention, Affiliated Hospital of Stomatology, Chongqing Medical University, Chongqing   400015, China;  3Department of Pathogenic Microorgamnism, Chongqing Medical University, Chongqing   400015, China
  • Received:2010-08-28 Revised:2010-09-26 Online:2011-03-12 Published:2011-03-12
  • Contact: Lin Ju-hong, Professor, Chief physician, Master’s supervisor Department of Endodontics, Affiliated Hospital of Stomatology, Chongqing Medical University, Chongqing 400015, China juhonglin@sina.com
  • About author:Du Bo★, Studying for Master‘s degree, Department of Endodontics, Affiliated Hospital of Stomatology, Chongqing Medical University, Chongqing 400015, China 03-0958@163.com
  • Supported by:

    the Foundation of Chongqing Health Bureau, No. 2008-2-243*

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Abstract:

BACKGROUND: Photodynamic therapy (PDT) may have bad effects on oral cavity tissue, so the biological safety evaluation is necessary before Toluidine blue O (TBO)-mediated PDT of dentine caries in clinic.
OBJECTIVE: To observe the effects of photosensitization of the TBO-mediated PDT to periodontal tissues in mice.
METHODS: Fifty-four mice were randomly divided into nine groups, and were respectively treated with 0 mg/L, 50 mg/L, 100 mg/L TBO with 0, 15, 25min LED illumination. Periodontal tissue slices were taken to observation after treatment of 72 hours.
RESULTS AND CONCLUSION: There were no abnormal changes like necrosis, ulcer or hyperplasia happens in the mice gingival, alveolar bone or teeth after light treatment. This indicated that TBO-mediated PDT was safe to the prevention of dental caries, without damaging effect to periodontal tissues adjacent to the teeth.

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