Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (49): 9163-.doi: 10.3969/j.issn.1673-8225.2010.49.010

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Intraarticular injection of bone marrow mesenchymal stem cells for treatment of early osteoarthritis detected by magnetic resonance

Liu Zhao1, Cui Yan-an1, Huang Hai-qing1, Zhou Zhong-heng1, Zhuang Chao2   

  1. 1 Department of MR, Jiangsu Province Hospital of Traditional Chinese Medicine, Nanjing  210029, Jiangsu Province, China; 2 Orthopaedics Center, Nanjing First Hospital Affiliated to Nanjing Medical University, Nanjing  210006, Jiangsu Province, China
  • Online:2010-12-03 Published:2010-12-03
  • Contact: Cui Yan-an, Associate chief physician, Department of MR, Jiangsu Province Hospital of Traditional Chinese Medicine, Nanjing 210029, Jiangsu Province, China cya6902@sohu.com
  • Supported by:

    the General Program of  Natural Science Foundation of Jiangsu Province, No.BK2009460*

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Abstract:

BACKGROUND: Authors have assessed the FS-3D-FISP sequence for diagnosis of osteoarthritis. This sequence has a good consistency of the grade and pathology of early osteoarthritis.
OBJECTIVE: To observe the thickness and signal changes by magnetic resonance (MR) in the treatment of on early osteoarthritis in rabbits using bone marrow mesenchymal stem cells (BMSCs) transplantation.
METHODS: New Zealand white rabbits were randomly and equally divided into a control group, osteoarthritis group and BMSCs group. Injection of BMSCs was given to the left knee joint of rabbits in the BMSCs group on week 4 after arthritis induction. MR of knee joints was done at 2 weeks, 1, 2 and 3 months after the injection; three rabbits were randomly selected every time from each group. Using the sequence of FS-3D-FISP, the thickness of articular cartilage was measured and the T2-FSE double-eho sequences were utilized to measure the changes of T2 value after treatment. Pathohistological changes were observed as well as Mankin scores. The effect of the osteoarthritis in rabbit was evaluated.
RESULTS AND CONCLUSION: Compared with osteoarthritis group, the thickness of articular cartilage got close to normal; T2 value reduced, and without arthroedema shown in magnetic resonance imaging. Results indicated that the thickness and signal changes of the articular cartilage on MR can be used to evaluate the changes in osteoarthritis pre- and post-treatment.

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