Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (45): 8503-8506.doi: 10.3969/j.issn.1673-8225.2010.45.034

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Effects of traditional Chinese medicine in the induction of stem cell differentiation into cardiomyocytes

Wang Dong-jin1, Shi Guang-fei2, Jiang Hong3, Yu Hong-song1   

  1. 1 Drum Tower Hospital, Department of Integrated Traditional and Western Medicine, First Clinical College, Nanjing University of Traditional Chinese Medicine, Nanjing  210008, Jiangsu Province, China; 2 Department of Cardiology, Drum Tower Hospital of Nanjing University Medical School, Nanjing  210008, Jiangsu Province, China; 3 First Clinical College, Nanjing University of Traditional Chinese Medicine, Nanjing 210046, Jiangsu Province, China　 
  • Online:2010-11-05 Published:2010-11-05
  • Contact: Shi Guang-fei, Doctor, Chief physician, Department of Cardiology, Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, Jiangsu Province, China njglxzsgf@yahoo.com.cn
  • About author:Wang Dong-jin☆, Doctor, Chief physician, Drum Tower Hospital, Department of Integrated Traditional and Western Medicine, First Clinical College, Nanjing University of Traditional Chinese Medicine, Nanjing 210008, Jiangsu Province, China gldjw@163.com
  • Supported by:

    the Science and Technology Projects of Health Department of Jiangsu Province, No. H200220*; the Key Medical Science and Technology Development Projects of Nanjing City, No. ZKX0206*

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Abstract:

BACKGROUND: Classical stem cell inducer due to its cytotoxicity only has been utilized in stem cell vitro experiment, which provides a challenge for elevating the therapeutic effect of stem cell transplantation. More and more studies have verified that traditional Chinese medicine as a new stem cell inducer can induce the differentiation of embryonic stem cells and bone marrow mesenchymal stem cells (BMSCs) into cardiomyocytes. This study group engaged in myocardial stem cell research for a long term. The alkaloid ligustrazine extracted from Szechwan Lovage Rhizome has successfully induced the differentiation of cardiac stem cells into cardiomyocytes in vitro.
OBJECTIVE: To summarize the advance in traditional Chinese medicine stem cell inducer and to provide a basis for the efficiency of stem cell differentiation into cardiomyocytes during cardiovascular diseases stem cell transplantation.
METHODS: Key words were “traditional Chinese medicine, stem cells, cardiomyocytes”. Foreign Medical Journal Service (www.kjmed.com.cn), Chinese journal full-text database, China Doctor Dissertations Full-text Database and China National Knowledge Infrastructure were searched for articles on the differentiation of stem cells into cardiomyocytes induced by traditional Chinese medicine published from 2005 to 2009. The repetitive studies were excluded. The retrieved literatures contained original articles, thesis and reviews.
RESULTS AND CONCLUSION: A total of 30 articles were included for this review, including 14 Chinese articles and 16 English articles. Results exhibited that traditional Chinese medicine as a new stem cell inducer not only effectively induced stem cell differentiation into cardiomyocytes, but also was characterized by no side or adverse effects. Therefore, it is hopeful to use in clinical stem cell therapy. It is new for traditional Chinese medicine to induce stem cell differentiation into cardiomyocytes. With deep research, more and more traditional Chinese medicine inducer will be found.

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