Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (40): 7568-7571.doi: 10.3969/j.issn.1673-8225.2010.40.036

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Bone marrow mesenchymal stem cell transplantation and pravastatin treatment via artery for early femoral head avascular necrosis

Li Biao, Liu Jin-song, Wang Kun   

  1. Department of Orthopaedics, First Affiliated Hospital, Kunming Medical University, Kunming  650000, Yunnan Province, China
  • Online:2010-10-01 Published:2010-10-01
  • About author:Li Biao☆, Studying for doctorate, Associate chief physician, Department of Orthopaedics, First Affiliated Hospital, Kunming Medical University, Kunming 650000, Yunnan Province, China a406364581@sina.com
  • Supported by:

     the Application Basic Association Foundation of Yunnan Province Department of Science and Technology-Kunming Medical University, No. 2008C0015R*

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Abstract:

BACKGROUND: Stem cell transplantation has recently been used to treat avascular necrosis of the femoral head. The onset of femoral head necrosis is associated with various reasons-induced ischemia in local tissue. Studies have found that the onset of femoral head necrosis may be correlated with decreased function of osteoblasts and bone marrow stromal cells.
OBJECTIVE: To investigate the feasibility of autologous bone marrow mesenchymal stem cell (BMSC) transplantation and pravastatin in treatment of avascular necrosis of femoral head in I – II phases via artery.
METHODS: A total of 32 patients (49 hips) with avascular necrosis of femoral head were selected. BMSCs were collected following mobilization of colony cell stimulating factors. 15 mL non-ionic contrast media were injected into the affected common iliac artery after successful puncture at the normal femoral artery by Seldinger technique. Autologous stem cell suspension was slowly injected twice through the catheter into the rotation, the lateral artery and obturator arteries, each injection longer than 5 minutes. After the surgery of interventional therapy, oral pravastatin was used. The patients were followed up after the operation. The clinical symptoms of avascular necrosis of femoral head and knee joint activity were evaluated.
RESULTS AND CONCLUSION: All 32 patients (49 hips) were followed up over 6 months postoperatively. Hip pain was lessened. Significant improvement in hip function was seen after treatment. The scope of joint activities was significantly expanded, and walking distance was increased. The abduction function was resumed significantly. Angiography of the femoral head in 16 patients (21 hips) at 6 months after treatment revealed that new blood vessels in the femoral head became more, and blood supply was improved. These suggest that BMSC transplantation and pravastatin treatment via artery on early femoral head necrosis have little damage, are well effective in functional recovery, can prevent or delay disease progress.

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