Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (40): 7555-7559.doi: 10.3969/j.issn.1673-8225.2010.40.033

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In vitro culture and homing mechanism of bone marrow mesenchymal stem cells

Qin Ji-zheng, Han Xiao-dong   

  1. Medical College, Nanjing University, Nanjing  210093, Jiangsu Province, China
  • Online:2010-10-01 Published:2010-10-01
  • Contact: Han Xiao-dong, Professor, Doctoral supervisor, Medical College, Nanjing University, Nanjing 210093, Jiangsu Province, China hanxd@nju.edu.cn
  • About author:Qin Ji-zheng★, Studying for Master’s degree, Medical College, Nanjing University, Nanjing 210093, Jiangsu Province, China qinjizheng@126.com

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Abstract:

BACKGROUND: Bone marrow mesenchymal stem cells (BMSCs) have multi-directional differentiation potential, and can subculture in vitro. Under special conditions, multiple factors participate in regulating BMSCs towards damaged tissue organs for repair and reestablishment.
OBJECTIVE: To review BMSCs homing mechanism and clinical application in the future.
METHODS: A computer-based online search was performed in SCI database for articles published from January 1999 to December 2008. The key words were “bone marrow mesenchymal stem cell, homing, clinical, therapy” in English. Totally 66 articles were retrieved.
RESULTS AND CONCLUSION: BMSCs are a kind of stem cells with potential of infinite proliferation and multi-directional differentiation, besides hematopoietic stem cells. Under special induced conditions, BMSCs can homing to a specific tissue and differentiate into corresponding tissue cells, resulting in playing repair and reestablishment effects. In addition, BMSCs are easy to be extracted, with strong amplification ability, no ethical problem or rejection. Therefore, BMSCs have a bright future in the clinical application to many obstinate diseases.

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