Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (40): 7535-7538.doi: 10.3969/j.issn.1673-8225.2010.40.028

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Biological characteristics of placenta-derived mesenchymal stem cells

Zhang Hong-yan, Yang Nai-long   

  1. Ward of Special Procurement, Hospital Affiliated to Medical College, Qingdao University, Qingdao  266003, Shandong Province, China
  • Online:2010-10-01 Published:2010-10-01
  • Contact: Yang Nai-long, Master, Chief physician, Master’s supervisor, Ward of Special Procurement, Hospital Affiliated to Medical College, Qingdao University, Qingdao 266003, Shandong Province, China nailongy@163.com
  • About author:Zhang Hong-yan★, Studying for master’s degree, Ward of Special Procurement, Hospital Affiliated to Medical College, Qingdao University, Qingdao 266003, Shandong Province, China hongyan128@163.com

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Abstract:

BACKGROUND: Recently, the study of mesenchymal stem cells (MSCs) makes some progresses, but there are still two major problems: lack of donor and immune rejection. Placenta-derived mesenchymal stem cells (PMSCs) have many advantages and may become a new source of MSCs.
OBJECTIVE: To study the progress in the isolation, culture and induced differentiation of PMSCs.
METHODS: A computer-based online search of Pubmed database was undertaken for the related articles published from 1993 to 2009 with the key words of “mesenchymal stem cells, placenta”. 180 literatures were retrieved and primarily checked. Repeated studies were excluded. Of the 41 selected literatures, 3 were reviews and the others were clinical or basic experiment study.
RESULTS AND CONCLUSION: Compared to research relatively large number of bone marrow mesenchymal stem cells, PMSCs due to a low immunogenicity, facilitated access to materials, non-invasive procedures, no ethical restrictions, large differentiation potential, proliferative ability, easy preparation and other characteristics of industrialization, become a key source of regenerative medicine and functional stem cells with the prospects for clinical application.

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