Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (19): 3578-3580.doi: 10.3969/j.issn.1673-8225.2010.19.033

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Research progress in epidermal stem cells

Xie Yi-fan, Wu Yan   

  1. Department of Histology and Embryology, Inner Mongolia Medical College, Hohhot 010059, Nei Monggol Autonomous Region, China
  • Online:2010-05-07 Published:2010-05-07
  • Contact: Wu Yan, Professor, Doctor, Master’s supervisor, Department of Histology and Embryology, Inner Mongolia Medical College, Hohhot 010059, Nei Monggol Autonomous Region, China yanw007@sina.com
  • About author:Xie Yi-fan, Studying for master’s degree, Department of Histology and Embryology, Inner Mongolia Medical College, Hohhot 010059, Nei Monggol Autonomous Region, China yfxie11@126.com
  • Supported by:

    Provincial and Departmental  Special Foundation for Higher Eduction Institute, No. [2005]1162*

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Abstract:

BACKGROUND: Epidermal stem cells have been paid great attention on the research of gene therapy and cell therapy with its specific biological advantages with the development of molecular biology, cell biology and bioengineering.
OBJECTIVE: To summarize relative research progress of epidermal stem cells.
METHODS: The first author retrieved PubMed database (http://www.ncbi.nlm.nih.gov/PubMed) for English articles published from January 2000 to January 2009. The key words were “epidermal stem cell, marker, clinical application”. Simultaneously, CNKI database (http://www.cnki.net/index.htm) was also retrieved for relevant Chinese articles published from January 2000 to January 2009. The key words were “epidermal stem cell, marker, clinical application”. A total of 815 articles were obtained, and finally 21 articles were included.
RESULTS AND CONCLUSION: To understand the research progress of source, distribution characteristics, identification method, proliferation, differentiation and regulation mechanisms, present clinical application of epidermal stem cells is the major premise and theoretical basis of epidermal stem cells for treating diseases. Epidermal stem cells have the potential of proliferation and multi-directional differentiation, and have important significances for maintaining epidermal self-renewal, keeping normal structure and repairing skin trauma. Epidermal stem cells have attracted more and more interest of researchers.

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