Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (19): 3573-3577.doi: 10.3969/j.issn.1673-8225.2010.19.032

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Main transcription factors and related mechanisms of embryonic stem cells differentiation into pancreatic endocrine cells

Zheng Yang1,2, Zhou Zuo-hong1, Hou Ling-ling3, Li Fang-hua2,4, Guan Wei-jun2, Ma Yue-hui2   

  1. 1College of Animal Science & Technology, Jiangxi Agricultural University, Nanchang   330045, Jiangxi Province, China;
    2Institute of Animal Science, Chinese Academy of Agricultural Science, Beijing  100193, China;
    3Institute of Biological Science and Technology, College of Science, Beijing Jiaotong University, Beijing 100044, China;
    4College of Animal Science & Technology, Shanxi Agricultural University, Taigu   030801, Shanxi Province, China
  • Online:2010-05-07 Published:2010-05-07
  • Contact: Guan Wei-jun, Investigator, Doctoral supervisor, Institute of Animal Science, Chinese Academy of Agricultural Science, Beijing 100193, China wjguan86@126.com Ma Yue-hui, Investigator, Doctoral supervisor, Institute of Animal Science, Chinese Academy of Agricultural Science, Beijing 100193, China yuehui.ma@263.net
  • About author:Zheng Yang, Studying for master’s degree, College of Animal Science & Technology, Jiangxi Agricultural University, Nanchang 330045, Jiangxi Province, China; Institute of Animal Science, Chinese Academy of Agricultural Science, Beijing 100193, China zhengyang2008228@163.com
  • Supported by:

    the National Natural Science Foundation of China, No. 30671539;
    the High and Innovative Technique Development Plan of “863 Program”, No. 2007AA10Z170*

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Abstract:

BACKGROUND: Islet endocrine cells to address the shortage of donor islet diabetes provide an effective way, which differentiate into islet β cells.
OBJECTIVE: To summary main transcription factors and relevant mechanisms during differentiation of embryonic stem cells (ESCs) into pancreatic endocrine cells, and to provide theoretical basis for treating diabetes mellitus.
METHODS: The first author retrieved PubMed database in computer for relevant literatures published from 1997 to 2009 in September 2009. The key words were “Embryonic stem cells; Transcription factors; Pancreatic endocrine cells”. Studies concerning main transcription factors and relevant mechanisms during differentiation of ESCs into pancreatic endocrine cells were included. Duplicated studies were excluded. Following screening titles and abstracts, 32 articles were included.
RESULTS AND CONCLUSION: Pancreatic endocrine cells are the major secretory sites of pancreas. They can secrete glucagon, insulin, somatostatin, pancreatic polypeptide and ghrelin, which make an important role in the regulation of blood glucose concentration. ESCs are a kind of multipotential stem cells, can differentiate into pancreatic endocrine cells with regulation of many genes and transcription factors involved in the process. However, present studies only focused on single transcription factor, and we should do further investigations on network regulation during occurrence and development of pancreas.

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