Meta-analysis of autologous bone marrow mesenchymal stem cell transplantation in the treatment of ischemic stroke

doi:10.12307/2021.145

Abstract

Abstract: OBJECTIVE: Clinical trials of mesenchymal stem cell transplantation for cerebrovascular diseases have been gradually carried out in the world. However, the sample size of the studies is small, and there is lack of evidence-based medical evidence. This article is designed to systematically assess the safety and efficacy of autologous bone marrow mesenchymal stem cell transplantation in the treatment of ischemic stroke using meta-analysis.
METHODS: Wanfang, VIP, CNKI, Cochrane Library, EMbase and PubMed databases were searched to collect clinical trials of bone marrow mesenchymal stem cell transplantation for ischemic stroke from January 2005 to May 2019. Two researchers independently performed literature screening, extraction of literature data and bias risk assessment of included literature according to inclusion and exclusion criteria, and used RevMan 5.3 software for meta-analysis.
RESULTS: (1) A total of 12 articles (ten were randomized controlled trials and two were non-randomized studies) with 786 ischemic stroke patients were included in the analysis. (2) Meta-analysis results showed that individual disability status (FIM score; MD=20.12, 95%CI: 3.26-36.97, P=0.02), neurological deficit (NIHSS score; MD=-2.09, 95%CI: -2.75 to -1.44, P < 0.000 01), motor function (FMA score; MD=12.24, 95%CI: 7.22-17.26, P < 0.000 01), and activities of daily living (BI score; MD=6.30, 95%CI: 5.11-7.49, P=0.005) in the autologous bone marrow mesenchymal stem cell transplantation group were superior to the control group.
CONCLUSION: The clinical evidence collected in the article shows that autologous bone marrow mesenchymal stem cell transplantation can effectively improve the motor function and daily living function of patients with ischemic stroke, with fewer adverse reactions. However, high-quality studies with multi-center, large-sample randomized controlled trials are required for further investigation on the clinical application of bone marrow mesenchymal stem cell transplantation.

Key words: stem cells, stroke, cerebral infarction, ischemic stroke, bone marrow mesenchymal stem cells, transplantation, exercise, meta-analysis

CLC Number:

Yuan Chunhua, Cui Zhenzhen, Wu De. Meta-analysis of autologous bone marrow mesenchymal stem cell transplantation in the treatment of ischemic stroke[J]. Chinese Journal of Tissue Engineering Research, 2021, 25(31): 5018-5024.

Figures/Tables 10

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