中国组织工程研究

中国组织工程研究 ›› 2026, Vol. 30 ›› Issue (25): 6496-6505.doi: 10.12307/2026.279

• 肌肉肌腱韧带组织构建 tissue construction of the muscle, tendon and ligament • 上一篇    下一篇

青少年磁性钙调线粒体敏感性：骨骼肌功能及身体成分评估

厉中山1，2，李文昊1，杜欣冉1，杨铁黎3，白  石4，5   

  1. 1东北大学体育部，辽宁省沈阳市   110819；2福建师范大学体育科学学院，福建省福州市   350117；3大理大学体育科学学院，云南省大理市   6710033；4沈阳工业大学信息科学与工程学院，辽宁省沈阳市   111003；5辽宁省磁医学检测与治疗专业技术创新中心，辽宁省沈阳市   110034
  • 收稿日期:2025-10-11 修回日期:2025-12-01 出版日期:2026-09-08 发布日期:2026-04-21
  • 通讯作者: 杨铁黎，大理大学体育科学学院，云南省大理市 6710033 通讯作者：白石，沈阳工业大学信息科学与工程学院，辽宁省沈阳市 111003；辽宁省磁医学检测与治疗专业技术创新中心，辽宁省沈阳市 110034
  • 作者简介:厉中山，男，博士，长聘副教授，沈阳市领军人才。
  • 基金资助:
    辽宁省科技计划联合计划(技术攻关计划项目)(173165312852)，项目负责人：厉中山；辽宁省国际合作项目(2023JH2/10700004)，项目负责人：白石；国家自然科学基金项目(62471320)，项目负责人：白石；兴辽人才计划项目(XLYC2203046)，项目负责人：白石

Magnetic calcium-regulated mitochondrial sensitivity in adolescents: assessment of skeletal muscle function and body composition

Li Zhongshan1, 2, Li Wenhao1, Du Xinran1, Yang Tieli3, Bai Shi4, 5   

  1. 1Department of Physical Education, Northeastern University, Shenyang 110819, Liaoning Province, China; 2School of Physical Education and Sport Science, Fujian Normal University, Fuzhou 350117, Fujian Province, China; 3School of Physical Education and 
  • Received:2025-10-11 Revised:2025-12-01 Online:2026-09-08 Published:2026-04-21
  • Contact: Yang Tieli, School of Physical Education and Sport Science, Dali University, Dali 671003, Yunnan Province, China Co-corresponding author: Bai Shi, School of Information Science and Engineering, Shenyang University of Technology, Shenyang 111003, Liaoning Province, China; Liaoning Provincial Magnetic Medicine Detection and Treatment Professional Technology Innovation Center, Shenyang 110034, Liaoning Province, China
  • About author:Sport Science, Dali University, Dali 671003, Yunnan Province, China; 4School of Information Science and Engineering, Shenyang University of Technology, Shenyang 111003, Liaoning Province, China; 5Liaoning Provincial Magnetic Medicine Detection and Treatment Professional Technology Innovation Center, Shenyang 110034, Liaoning Province, China Li Zhongshan, PhD, Associate professor, Department of Physical Education, Northeastern University, Shenyang 110819, Liaoning Province, China; School of Physical Education and Sport Science, Fujian Normal University, Fuzhou 350117, Fujian Province, China
  • Supported by:
    Liaoning Provincial Science and Technology Joint Program (Technology Breakthrough Program), No. 173165312852 (to LZS); Liaoning Provincial International Cooperation Project, No. 2023JH2/10700004 (to BS); National Natural Science Foundation of China, No. 62471320 (to BS); Xingliao Talent Program, No. XLYC2203046 (to BS) 

PDF

2

摘要：



文题释义：
磁场线粒体调控技术：是一种非侵入性的骨骼肌功能促进手段，在改善肌肉功能、促进代谢等方面已得到有效证实。采用特定参数的低频脉冲磁刺激可激活经典瞬时受体电位通道1，进而触发钙-线粒体轴级联反应，该生理过程通过上调过氧化物酶体增殖物激活受体γ共激活因子1α的转录活性，显著增强线粒体生物发生与肌生成能力。低频脉冲磁场诱导的钙离子内流可特异性激活钙调神经磷酸酶-T细胞活化核因子信号通路，触发骨骼肌适应性重塑的关键分子开关，成功模拟了运动训练诱导的代谢适应特征，可对骨骼肌功能与结构产生一系列生理支持与适应变化。

背景：磁性钙调线粒体技术作为非侵入性的骨骼肌功能促进手段，在改善肌肉功能、促进代谢敏感性等方面已得到有效证实，现有研究表明该技术对成年、老年及术后康复群体具有显著生理促进效应，但该技术对十二三岁青少年骨骼肌功能及身体成分的干预效应尚未明确。
目的：通过对骨骼肌功能及身体成分的评估，探究十二三岁青少年骨骼肌功能及身体成分对磁刺激的敏感性。
方法：招募辽宁省实验学校初中一年级学生，共计34人，随机分为对照组、试验组，对照组保持学生日常校园活动外，无专门体能训练计划，在此基础上试验组每周进行2次低频脉冲磁场干预(刺激时长10 min，磁场强度1.5 mT，频率3 300 Hz，间隔72 h干预1次)，连续4周。试验开始前(前测)和结束后(后测)观察受试者干预部位的最大力量、爆发力、耐力素质以及身体成分相关指标的变化。
结果与结论：①经过4周共8次的低频脉冲磁场刺激，受试的爆发力、有氧耐力、肌肉等长耐力、身体成分相关指标均有了显著的改善，可表明十二三岁青少年对上述骨骼肌功能与身体成分具有良好的磁性钙调刺激敏感性。②在最大力量提升方面效果不显著，其肌肉磁敏感性较成年人低，但在长期久坐状况下对于最大力量保持方面具有一定优势。结果表明，磁性钙调线粒体技术作为一种全新的被动、非侵入性的骨骼肌功能促进技术可尝试用作改善青少年体质健康的一项全新干预手段。

https://orcid.org/0000-0002-9010-609X (厉中山) 


中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

关键词: 青少年体质, 肌肉力量, 体成分, 磁刺激, TRPC 1, 身体素质敏感期, 肌肉分泌组

Abstract: BACKGROUND: Magnetic mitochondrial calcium regulation technology, as a non-invasive method for promoting skeletal muscle function, has been effectively demonstrated in improving muscle function and enhancing metabolic sensitivity. Existing studies have shown that this technology has significant physiological promoting effects on adults, the elderly, and postoperative rehabilitation groups. However, its intervention effect on skeletal muscle function and body composition in 12-13-year-old adolescents remains unclear.
OBJECTIVE: To explore the sensitivity of skeletal muscle function and body composition in 12-13-year-old adolescents to magnetic stimulation by assessing their skeletal muscle function and body composition.
METHODS: Thirty-four junior high school students in Grade 7 from Liaoning Province Experimental School were recruited and randomly divided into a control group and a trial group. The control group maintained their daily school activities without any specific physical training plan. In addition, the trial group received low-frequency pulsed magnetic field intervention twice a week (stimulation duration 10 minutes, magnetic field strength 1.5 mT, frequency 3 300 Hz, intervention once every 72 hours) for four consecutive weeks. Changes in maximum strength, explosive power, endurance, and body composition-related indicators at the intervention sites were observed before the start of the trial (pre-test) and after the end of the trial (post-test). 
RESULTS AND CONCLUSION: (1) After 8 sessions of low-frequency pulsed magnetic field stimulation over 4 weeks, the subjects showed significant improvements in explosive power, aerobic endurance, isometric endurance, and body composition-related indicators, indicating that 12-13-year-old adolescents had good sensitivity to magnetic calcium regulation stimulation for the aforementioned skeletal muscle function and body composition. (2) The effect on maximum strength improvement was not significant, and their muscle magnetic sensitivity was lower than that of adults, but they showed some advantages in maintaining maximum strength under prolonged sedentary conditions. These results suggest that magnetic mitochondrial calcium regulation technology, as a novel passive and non-invasive skeletal muscle function enhancement technique, could be explored as a novel intervention to improve the physical health of adolescents.

Key words: adolescent physique, muscle strength, body composition, magnetic stimulation, TRPC 1, sensitive period for physical fitness, muscle secretion group

中图分类号: