中国组织工程研究

中国组织工程研究 ›› 2025, Vol. 29 ›› Issue (34): 7461-7469.doi: 10.12307/2025.884

• 生物材料相关大数据分析 Big data analysis of biomaterials • 上一篇    下一篇

富血小板血浆制备装置专利的技术分析

阙  梦1，2，高峰青1，2，何  杨3，阮长耿3   

  1. 苏州大学，1血液和血管疾病诊疗药物技术教育部工程研究中心，2唐仲英血液学研究中心，江苏省苏州市   215000；3苏州大学附属第一医院，江苏省苏州市   215000
  • 收稿日期:2024-08-21 接受日期:2024-10-11 出版日期:2025-12-08 发布日期:2025-01-18
  • 作者简介:阙梦，女，1990年生，江苏省无锡市人，汉族，硕士，助理研究员，主要从事血液学研究。
  • 基金资助:
    国家自然科学基金项目(82070123)，项目名称：脂联素及其受体AdipoR1促进血小板生成和免疫耐受干预免疫性血小板减少症的机制研究，项目负责人：何杨

Patent technology analysis of platelet-rich plasma preparation devices

Que Meng1, 2, Gao Fengqing1, 2, He Yang3, Ruan Changgeng3   

  1. 1Ministry of Education Engineering Center of Hematological Disease, 2Cyrus Tang Hematology Center, Soochow University, Suzhou 215000, Jiangsu Province, China; 3First Affiliated Hospital of Soochow University, Suzhou 215000, Jiangsu Province, China
  • Received:2024-08-21 Accepted:2024-10-11 Online:2025-12-08 Published:2025-01-18
  • About author:Que Meng, MS, Assistant research fellow, Ministry of Education Engineering Center of Hematological Disease, and Cyrus Tang Hematology Center, Soochow University, Suzhou 215000, Jiangsu Province, China
  • Supported by:
    National Natural Science Foundation of China, No. 82070123 (to HY)

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摘要：


文题释义：

富血小板血浆：是通过离心方法从自体血中提取出来的血小板浓缩物。基于制备体系的差异，大多数富血小板血浆中的血小板浓度是外周血的4-8倍。富血小板血浆含有高浓度的血小板、白细胞和纤维蛋白，血小板含有的多种生长因子能促进细胞增殖，白细胞可以抵抗感染，纤维蛋白能在局部构建组织修复的三维结构，加速组织的修复。富血小板血浆来源于自体，无免疫排斥反应，安全有效。
专利技术分析：是在对专利进行定量分析或定性分析的基础上，制作与技术相关的专利分析图表，并对图表进行解读得出相关结论的方法。专利技术分析可以反映某一技术的发展趋势、生命周期、发展路线、技术热点/空白点等。专利技术分析的结论通常能为技术的开发和利用提供参考依据。


背景：富血小板血浆是组织修复的重要材料，被广泛应用于骨科、创面修复、整形美容等领域，而制备富血小板血浆的装置随即成为专利申请领域的热点。

目的：分析国内外富血小板血浆制备装置的专利申请趋势。
方法：利用国家知识产权局专利检索系统、Patsnap和Himpat专利数据库检索富血小板血浆分离装置的专利文献，从专利申请量、授权率、技术主题、典型申请人专利布局等方面对富血小板血浆制备装置专利申请趋势进行分析。国家知识产权局专利检索系统由中国知识产权局开发，收录了103个国家、地区和组织的专利数据。Patsnap专利数据库由新加坡的智慧芽公司开发，拥有100多个国家1.2亿的专利数据，提供多语言翻译、多语言搜索。Himpat专利数据库由中国Himpat公司开发，收录全球123个国家/组织/地区自1800年以来超过1.6亿项专利，并翻译为高保真中文和英文版本，保持每周2次更新。

结果与结论：中国富血小板血浆制备装置的专利申请起步晚于国外10年左右，从2017年开始中国专利申请量急剧上升；国外的专利申请量趋势较平稳。国内外的专利申请大多处于授权且维持阶段，主要申请人以企业为主。市面上的富血小板血浆制备装置分类十分混乱，此次研究根据装置结构将其分成9种细分类，中国专利申请主要集中于分离筒式装置，国外则集中于自动化分离装置。中国要以市场和技术为导向，研发创新力强的富血小板血浆制备装置，做好全球专利布局，推动中国医疗器械行业发展。

https://orcid.org/0009-0008-7867-9806 (阙梦) 

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料；口腔生物材料；纳米材料；缓释材料；材料相容性；组织工程

关键词: 富血小板血浆制备装置, 富血小板血浆, 专利布局, 专利技术, 工程化材料

Abstract: BACKGROUND: Platelet-rich plasma is an important material for tissue repair and is widely used in orthopedics, wound repair, plastic surgery and other fields. The device for preparing platelet-rich plasma has become a hot spot in the field of patent applications. 
OBJECTIVE: To analyze the trend of patent applications for platelet-rich plasma separation devices at home and abroad. 
METHODS: Using the patent retrieval system of China National Intellectual Property Administration, Patsnap and Himpat patent databases, we searched the patent literature of platelet-rich plasma separation devices, and analyzed the patent application trend of platelet-rich plasma separation devices from the aspects of patent application volume, licensing rate, technical theme, typical applicant patent layout, etc. The patent retrieval system of China National Intellectual Property Administration was developed by the China National Intellectual Property Administration and includes patent data from 103 countries, regions and organizations. The Patsnap patent database was developed by PatSnap, Singapore and has 120 million patent data from more than 100 countries, providing multi-language translation and multi-language search. The Himpat patent database was developed by Himpat, China and includes more than 160 million patents from 123 countries/organizations/regions around the world since 1800, and is translated into high-fidelity Chinese and English versions, and is updated twice a week.
RESULTS AND CONCLUSION: The patent application for platelet-rich plasma separation devices in China started about 10 years later than abroad, and the number of patent applications in China has sharply increased since 2017. The trend of patent applications abroad is relatively stable. Most domestic and foreign patent applications are in the stage of authorization and maintenance, with enterprises being the main applicants. The classification of platelet-rich plasma devices on the market is very confusing. In this study, they are divided into nine subcategories based on device structure. Chinese patent applications mainly focus on separation cylinder devices, while foreign applications focus on automated separation devices. China should be market-oriented and technology oriented, develop innovative platelet-rich plasma devices, lay out global patent layouts, and promote the development of China’s medical device industry.

Key words: platelet-rich plasma preparation device, platelet-rich plasma, patent layout, patent technology, engineered material

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