中国组织工程研究

中国组织工程研究 ›› 2023, Vol. 27 ›› Issue (25): 3937-3941.doi: 10.12307/2023.548

• 材料生物相容性 material biocompatibility •    下一篇

医用创面敷料阻血液传播病原体的穿透性能

师广波1，2，李秀婷1，2，刘兴翠1，2，国宪虎1，2，李珑斐3，王文庆1，2   

  1. 1山东省医疗器械和药品包装检验研究院微生物室，山东省济南市  250101；2国家药品监督管理局医用卫生材料及生物防护器械质量评价重点实验室，山东省济南市  250101；3山东省医疗器械和药品包装检验研究院业务受理办公室，山东省济南市  250101
  • 收稿日期:2022-08-03 接受日期:2022-09-24 出版日期:2023-09-08 发布日期:2023-01-18
  • 通讯作者: 王文庆，高级工程师，山东省医疗器械和药品包装检验研究院微生物室，山东省济南市 250101；国家药品监督管理局医用卫生材料及生物防护器械质量评价重点实验室，山东省济南市 250101
  • 作者简介:师广波，男，1988年生，山东省菏泽市人，汉族，硕士，工程师，主要从事医疗器械检测、科研及标准化工作。

Ability of medical wound dressings to resist penetration of bloodborne pathogens

Shi Guangbo1, 2, Li Xiuting1, 2, Liu Xingcui1, 2, Guo Xianhu1, 2, Li Longfei3, Wang Wenqing1, 2   

  1. 1Microbe Inspection Department, Shandong Institute of Medical Device and Pharmaceutical Packaging Inspection, Jinan 250101, Shandong Province, China; 2Key Laboratory for Quality Evaluation of Medical Materials and Biological Protective Devices, National Medical Products Administration, Jinan 250101, Shandong Province, China; 3Sample Receiving Department, Shandong Institute of Medical Device and Pharmaceutical Packaging Inspection, Jinan 250101, Shandong Province, China
  • Received:2022-08-03 Accepted:2022-09-24 Online:2023-09-08 Published:2023-01-18
  • Contact: Wang Wenqing, Senior engineer, Microbe Inspection Department, Shandong Institute of Medical Device and Pharmaceutical Packaging Inspection, Jinan 250101, Shandong Province, China; Key Laboratory for Quality Evaluation of Medical Materials and Biological Protective Devices, National Medical Products Administration, Jinan 250101, Shandong Province, China
  • About author:Shi Guangbo, Master, Engineer, Microbe Inspection Department, Shandong Institute of Medical Device and Pharmaceutical Packaging Inspection, Jinan 250101, Shandong Province, China; Key Laboratory for Quality Evaluation of Medical Materials and Biological Protective Devices, National Medical Products Administration, Jinan 250101, Shandong Province, China

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摘要：

文题释义：

医用创面敷料：是用于接触创面的任何性状、形态或规格的材料或组合材料，可作为创面的机械屏障，用于分泌物的吸收或引流，以控制创面的微生物环境，能直接或间接促进创面愈合。
穿透：在医用创面敷料材料上，液体以非分子水平方式穿过包裹物、多孔材料、孔隙或其他缺陷处的地方。

背景：医用创面敷料的阻菌性测试方法已经非常成熟，而对其阻血液传播病原体穿透性能的测试方法还是一片空白，且随着敷料行业的精细化发展，市场需求逐渐增多。
目的：通过模拟不同临床使用条件，研究4种类型医用敷料阻血液传播病原体的穿透性能。
方法：选用薄膜敷料、聚氨酯泡沫敷料、水胶体敷料和无纺布敷料4种临床上常见的医用创面敷料，利用半湿态(外干内湿)和湿态两种方法模拟临床使用环境，采用噬菌体Phi-X174进行穿透挑战实验。

结果与结论：①无纺布敷料有噬菌体Phi-X174穿透形成的噬菌斑，薄膜敷料、聚氨酯泡沫敷料及水胶体敷料没有噬菌体Phi-X174穿透形成的噬菌斑；②结果显示，无纺布敷料无阻止噬菌体穿透性能，薄膜敷料、聚氨酯泡沫敷料、水胶体敷料均具有阻止噬菌体穿透的性能。

https://orcid.org/0000-0003-1340-3653(师广波)

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料；口腔生物材料；纳米材料；缓释材料；材料相容性；组织工程

关键词: 医用创面敷料, 血液传播病原体, 穿透, 噬菌体, 噬菌斑

Abstract: BACKGROUND: The methods for testing the bacterial barrier properties of medical wound dressings are available; however, the ability of medical wound dressings to resist penetration of bloodborne pathogens still needs further study.
OBJECTIVE: To investigate the ability of four kinds of wound dressings to resist penetration of bloodborne pathogens by simulating clinical conditions.
METHODS: The abilities of four kinds of wet-to-dry wound dressings (nonwoven, film, polyurethane foam, and hydrocolloid dressings) to resist penetration of bloodborne pathogens were tested using Phi-X174 Bacteriophage Penetration Test System. 
RESULTS AND CONCLUSION: (1) The nonwoven dressing had plaques formed by the penetration of phage Phi-X174, however, the film, polyurethane foam, and hydrocolloid dressings did not have plaques formed by the penetration of phage Phi-X174. (2) These results suggest that the film, polyurethane foam, and hydrocolloid dressings, but not the nonwoven dressing have the ability to resist penetration of bloodborne pathogens.

Key words: medical wound dressings, bloodborne pathogens, penetration, phage, plaques

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